G0668

GW2974

≥98% (HPLC), solid

• Synonym(e): N4-(1-Benzyl-1H-indazol-5-yl)-N6,N6-dimethyl-pyrido­[3,4-d]­pyrimidine-4,6-diamine
• Empirische Formel (Hill-System): C₂₃H₂₁N₇
• CAS-Nummer: 202272-68-2
• Molekulargewicht: 395.46
• MDL-Nummer: MFCD04974495
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24278451
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: solid
• Farbe: yellow
• Löslichkeit: DMSO: ≥20 mg/mL
• Ersteller: GlaxoSmithKline
• SMILES String: CN(C)c1cc2c(Nc3ccc4n(Cc5ccccc5)ncc4c3)ncnc2cn1
• InChI: 1S/C23H21N7/c1-29(2)22-11-19-20(13-24-22)25-15-26-23(19)28-18-8-9-21-17(10-18)12-27-30(21)14-16-6-4-3-5-7-16/h3-13,15H,14H2,1-2H3,(H,25,26,28)
• InChIKey: DYYZXRCFCVDSKD-UHFFFAOYSA-N
• Angaben zum Gen: human ... EGFR(1956) , ERBB2(2064)

Beschreibung

Biochem./physiol. Wirkung

Potent and selective dual inhibitor of EGFR (IC₅₀ = 0.016 mM) and ErbB-2 receptor tyrosine kinase.

Leistungsmerkmale und Vorteile

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Rechtliche Hinweise

Sold for research purposes under agreement from Glaxo­Smith­Kline

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)