E2387

NECA

≥98% (TLC), powder, adenosine receptor agonist

• Synonym(e): NECA
• Empirische Formel (Hill-System): C₁₂H₁₆N₆O₄
• CAS-Nummer: 35920-39-9
• Molekulargewicht: 308.29
• MDL-Nummer: MFCD00069195
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24277684
• NACRES: NA.77

Eigenschaften

• product name: 5′-(N-Ethylcarboxamido)adenosine, powder
• Form: powder
• Qualitätsniveau: 200
• Farbe: white
• Löslichkeit: 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.2 mg/mL (Solutions may be stored for several days at 4 °C.); DMSO: 14 mg/mL (Solutions may be stored for several days at 4 °C.); 0.1 M HCl: 3.4 mg/mL (Solutions may be stored for several days at 4 °C.); H₂O: insoluble; ethanol: soluble (Solutions may be stored for several days at 4 °C.)
• Lagertemp.: 2-8°C
• SMILES String: CCNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)ncnc23
• InChI: 1S/C12H16N6O4/c1-2-14-11(21)8-6(19)7(20)12(22-8)18-4-17-5-9(13)15-3-16-10(5)18/h3-4,6-8,12,19-20H,2H2,1H3,(H,14,21)(H2,13,15,16)/t6-,7+,8-,12+/m0/s1
• InChIKey: JADDQZYHOWSFJD-FLNNQWSLSA-N
• Angaben zum Gen: human ... ADORA1(134) , ADORA2A(135) , ADORA2B(136) , ADORA3(140) ; rat ... Adora1(29290) , Adora2a(25369) , Adora2b(29316) , Adora3(25370)

Beschreibung

Allgemeine Beschreibung

5′-(N-Ethylcarboxamido)adenosine stimulates vasodilation in the pulmonary circulation through A₂-adenosine-receptor activation.

Anwendung

5′-(N-Ethylcarboxamido)adenosine has been used:

• for the purification of human adenosine A_2Areceptor (A_2AR) in decylmaltoside (DM)
• to determine nonspecific binding of adenosine receptors
• to investigate adenosine 2B receptor (RA2B) mechanism of action by competition assay

Biochem./physiol. Wirkung

Potent adenosine receptor agonist with nearly equal affinity at A₁ and A₂ receptors.

Leistungsmerkmale und Vorteile

This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• H-Sätze: H300
• P-Sätze: P264 - P301 + P310
• Gefahreneinstufungen: Acute Tox. 2 Oral
• Lagerklassenschlüssel: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges