SML3067

WM-1119

≥98% (HPLC)

• Synonym(e): 2-Fluoro-N′-(3-fluoro-5-(pyridin-2-yl)benzoyl)benzenesulfonohydrazide, 3-Fluoro-N′-(2-fluorophenyl)sulfonyl-5-(2-pyridyl)benzohydrazide, WM 1119, WM1119
• Empirische Formel (Hill-System): C₁₈H₁₃F₂N₃O₃S
• CAS-Nummer: 2055397-28-7
• Molekulargewicht: 389.38
• MDL-Nummer: MFCD31690337
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 2 mg/mL, clear
• Lagertemp.: 2-8°C
• SMILES String: FC1=CC(C2=NC=CC=C2)=CC(C(NNS(C3=CC=CC=C3F)(=O)=O)=O)=C1

Beschreibung

Biochem./physiol. Wirkung

WM-1119 is a potent and selective, acetyl coenzyme A (Acetyl-CoA)-competitive inhibitor against MYST family histone acetyltransferases KAT6A and KAT6B (KAT6B Kd = 2.1 nM by SPR, IC50 = 37 nM by activity assay; KAT7/5 Kd = 0.53/2.2 μM; no affinity toward 159 diverse biological targets). WM-1119 induces MEF G1 cell cycle arrest (1-10 μM), inhibits EMRK1184 lymphoma growth in cultures (IC50 = 250 nM) and in mice in vivo (50 mg/kg 3x or 4x i.p. per day).

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable