EPS002

MS-275

A HDAC1 and HDAC3 inhibitor

• Synonym(e): MS-275 (Entinostat, SNDX-275), 3-pyridinylmethyl [[4-[[(2-aminophenyl)amino]carbonyl]phenyl]methyl]carbamate, N-(2-Aminophenyl)-4-[N-(pyridine-3ylmethoxycarbonyl)aminomethyl]benzamide
• Empirische Formel (Hill-System): C₂₁H₂₀N₄O₃
• CAS-Nummer: 209783-80-2
• Molekulargewicht: 376.41
• MDL-Nummer: MFCD03453552
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329799578
• NACRES: NA.41

Eigenschaften

• Assay: ≥99%
• Löslichkeit: DMSO: 38 mg/mL
• Lagertemp.: −20°C
• SMILES String: Nc1ccccc1NC(=O)c2ccc(CNC(=O)OCc3cccnc3)cc2
• InChI: 1S/C21H20N4O3/c22-18-5-1-2-6-19(18)25-20(26)17-9-7-15(8-10-17)13-24-21(27)28-14-16-4-3-11-23-12-16/h1-12H,13-14,22H2,(H,24,27)(H,25,26)
• InChIKey: INVTYAOGFAGBOE-UHFFFAOYSA-N
• Angaben zum Gen: human ... HDAC1(3065) , HDAC10(83933) , HDAC11(79885) , HDAC2(3066) , HDAC3(8841) , HDAC4(9759) , HDAC5(10014) , HDAC6(10013) , HDAC7(51564) , HDAC8(55869) , HDAC9(9734)

Beschreibung

Allgemeine Beschreibung

Preferentially inhibits HDAC1 (IC₅₀=300 nM) over HDAC3 (IC₅₀=8 μM). Has no inhibitory activity towards HDAC8 (IC₅₀>100 μM).

Anwendung

MS-275 has been used as a histone deacetylase-1 inhibitor.

Biochem./physiol. Wirkung

HDAC inhibitor; antiproliferative.

Sicherheitshinweise

• Piktogramme: GHS06,GHS08
• Signalwort: Danger
• H-Sätze: H301,H360
• P-Sätze: P202 - P264 - P280 - P301 + P310 - P405 - P501
• Gefahreneinstufungen: Acute Tox. 3 Oral - Repr. 1A
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable