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Merck

E4660

Sigma-Aldrich

Eupatorin

≥97% (HPLC)

Synonym(e):

3′,5-Dihydroxy-4′,6,7-trimethoxy-flavon, 5-Hydroxy-2-(3-hydroxy-4-methoxy-phenyl)-6,7-dimethoxy-4H-1-benzopyran-4-on, 6-Methoxy-luteolin-4′,7-dimethylether, NSC 106402

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About This Item

Empirische Formel (Hill-System):
C18H16O7
CAS-Nummer:
Molekulargewicht:
344.32
MDL-Nummer:
UNSPSC-Code:
12352200
PubChem Substanz-ID:
NACRES:
NA.77

Assay

≥97% (HPLC)

Form

powder

Farbe

white to beige

Löslichkeit

DMSO: >10 mg/mL

Lagertemp.

room temp

SMILES String

COc1ccc(cc1O)C2=CC(=O)c3c(O)c(OC)c(OC)cc3O2

InChI

1S/C18H16O7/c1-22-12-5-4-9(6-10(12)19)13-7-11(20)16-14(25-13)8-15(23-2)18(24-3)17(16)21/h4-8,19,21H,1-3H3

InChIKey

KLAOKWJLUQKWIF-UHFFFAOYSA-N

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Anwendung

Eupatorin has been used as reference standard for characterization of Artemisia extracts using mass spectrometry (MS).

Biochem./physiol. Wirkung

Eupatorin acts as an antiproliferative in cells expressing the CYP1A- family. It induces G2/M block follow by apoptosis in cells expressing the CYP1A- family. It also functions as an anti-inflammatory.

Piktogramme

Exclamation mark

Signalwort

Warning

H-Sätze

Gefahreneinstufungen

Acute Tox. 4 Oral

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


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Hymecromon European Pharmacopoeia (EP) Reference Standard

Y0000011

Hymecromon

Yan Pan et al.
Journal of ethnopharmacology, 133(2), 881-887 (2010-11-26)
Andrographis paniculata (AP), Centella asiatica (CA) and Orthosiphon stamineus (OS) are three popular herbs traditionally used worldwide. AP is known for the treatment of infections and diabetes and CA is good for wound healing and healthy skin while OS is
Anna-Leena Salmela et al.
Experimental cell research, 318(5), 578-592 (2012-01-10)
The spindle assembly checkpoint (SAC) is a conserved mechanism that ensures the fidelity of chromosome distribution in mitosis by preventing anaphase onset until the correct bipolar microtubule-kinetochore attachments are formed. Errors in SAC function may contribute to tumorigenesis by inducing
I M Lyckander et al.
Prostaglandins, leukotrienes, and essential fatty acids, 54(4), 239-246 (1996-04-01)
15-Lipoxygenase from soybeans is inactivated by bubbling air through enzyme solutions. This inactivation is prevented by flavonoids from the East Asian medicinal plant Orthosiphon spicatus, previously found to be inhibitors of the enzyme. 5,7,4'-Trimethylapigenin, eupatorin and 5,7,3',4'-tetramethylluteolin show the strongest
Bioactive Phenolics of the Genus Artemisia (Asteraceae): HPLC-DAD-ESI-TQ-MS/MS Profile of the Siberian Species and Their Inhibitory Potential Against
Olennikov DN, et al.
Frontiers in Pharmacology, 9 (2018)
Mun Fei Yam et al.
Journal of acupuncture and meridian studies, 5(4), 176-182 (2012-08-18)
Orthosiphon stamineus extracts contain three flavonoids (3'-hydroxy-5,6,7,4'-tetramethoxyflavone, sinensetin, and eupatorin) as bioactive substances. Previous reported high performance liquid chromatography- ultraviolet (HPLC-UV) methods for the determination of these flavonoids have several disadvantages, including unsatisfactory separation times and not being well validated

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