Direkt zum Inhalt
Merck
Alle Fotos(5)

Key Documents

View All Documentation

C6645

Sigma-Aldrich

Cytosin β-D-Arabinofuranosid -hydrochlorid

crystalline

Synonym(e):

Ara-C -hydrochlorid, Cytarabin -hydrochlorid

Anmeldenzur Ansicht organisationsspezifischer und vertraglich vereinbarter Preise
Alle Fotos(5)

About This Item

Empirische Formel (Hill-System):
C9H13N3O5 · HCl
CAS-Nummer:
69-74-9
Molekulargewicht:
279.68
EG-Nummer:
200-713-9
MDL-Nummer:
MFCD00012839
UNSPSC-Code:
12352202
PubChem Substanz-ID:
24278329
NACRES:
NA.77

Biologische Quelle

synthetic (inorganic)

Qualitätsniveau

200

Assay

≥99% (HPLC)

Form

crystalline

mp (Schmelzpunkt)

197-198 °C (lit.)

Lagertemp.

2-8°C

SMILES String

Cl[H].NC1=NC(=O)N(C=C1)[C@@H]2O[C@H](CO)[C@@H](O)[C@@H]2O

InChI

1S/C9H13N3O5.ClH/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8;/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16);1H/t4-,6-,7+,8-;/m1./s1

InChIKey

KCURWTAZOZXKSJ-JBMRGDGGSA-N

Angaben zum Gen

human ... POLA1(5422) , POLA2(23649) , POLD1(5424) , POLD2(5425) , POLD3(10714) , POLD4(57804) , POLE(5426) , POLE2(5427) , POLE3(54107) , PRIM1(5557) , PRIM2(5558)

Suchen Sie nach ähnlichen Produkten? Aufrufen Leitfaden zum Produktvergleich

Verwandte Kategorien

Anwendung

Cytosine β-D-arabinofuranoside hydrochloride has been used in fetal bovine serum supplemented Dulbecco′s modified eagle medium (FBS-DMEM) and B27/neurobasal-A medium to inhibit the growth of glial cells. It has also been used to inhibit astrocyte proliferation in embryonic spinal cord neurons.

Biochem./physiol. Wirkung

Ara-C is phosphorylated to Ara-CTP and is incorporatee into DNA. It inhibits DNA replication by forming cleavage complexes with topoisomerase I resulting in DNA fragmentation, and ultimately induces apoptosis via the PKC signaling pathway. Does not inhibit RNA synthesis. Anti-leukemia agent.

Sonstige Hinweise

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Piktogramme

Health hazardExclamation mark
GHS08,GHS07

Signalwort

Warning

Gefahreneinstufungen

Eye Irrit. 2 - Muta. 2 - Repr. 2 - Skin Sens. 1

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

Besitzen Sie dieses Produkt bereits?

In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Reduced activity of AMP-activated protein kinase protects against genetic models of motor neuron disease
Lim MA, et al.
The Journal of Neuroscience, 32(3), 1123-1141 (2012)
Vindhya Vijay et al.
Leukemia research, 84, 106180-106180 (2019-07-13)
One of the greatest challenges in treating acute myeloid leukemia (AML) is chemotherapy refractory disease. Previously, we demonstrated a novel mechanism whereby AML-induced endothelial cell (EC) activation leads to subsequent leukemia cell adherence, quiescence and chemoresistance, identifying activated ECs as
JNK plays a key role in tau hyperphosphorylation in Alzheimer's disease models
Ploia C, et al.
Journal of Alzheimer'S Disease, 26(2), 315-329 (2011)
Juan A Godoy et al.
Molecular neurobiology, 55(12), 8965-8977 (2018-04-06)
Mitochondria are widely recognized as fundamental organelles for cellular physiology and constitute the main energy source for different cellular processes. The location, morphology, and interactions of mitochondria with other organelles, such as the endoplasmic reticulum (ER), have emerged as critical
Joost J Leenders et al.
The Journal of biological chemistry, 285(35), 27449-27456 (2010-06-23)
Pathological forms of left ventricular hypertrophy (LVH) often progress to heart failure. Specific transcription factors have been identified that activate the gene program to induce pathological forms of LVH. It is likely that apart from activating transcriptional inducers of LVH
Alle zugehörigen Dokumente anzeigen

Artikel

DNA Damage and Repair

DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.

Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..

Setzen Sie sich mit dem technischen Dienst in Verbindung.