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Cathepsin G from human leukocytes
lyophilized powder, ≥60 units/mg protein (Bradford)
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About This Item
CAS-Nummer:
MDL-Nummer:
UNSPSC-Code:
12352200
NACRES:
NA.32
Empfohlene Produkte
Biologische Quelle
human leucocytes
Qualitätsniveau
Form
lyophilized powder
Spezifische Aktivität
≥60 units/mg protein (Bradford)
Mol-Gew.
23-30 kDa
UniProt-Hinterlegungsnummer
Versandbedingung
dry ice
Lagertemp.
−20°C
Angaben zum Gen
human ... CTSG(1511)
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Allgemeine Beschreibung
Cathepsin G from human leukocytes is a neutral proteinase secreted by neutrophil granulocytes. It belongs to the family of serine proteases. Cathepsin G is a glycoprotein, which contains 1% carbohydrate. The gene is located on human chromosome 14q12.
Anwendung
Cathepsin G from human leukocytes has been used to determine protease sensitivity. It has also been used for the stimulation and staining of dendritic cells and macrophage.
Biochem./physiol. Wirkung
Cathepsin G from human leukocytes degrades various proteins, such as elastin, collagen, fibrinogen and immunoglobin. It may be implicated in muscle catabolism. Cathepsin G is involved in the activation or inactivation of protein hormones and the inactivation of plasma proteinase inhibitors. It alters the cytoskeleton, enhances the permeability of vascular endothelial cells and the chemotaxis of inflammatory cells. Cathepsin G is associated with autoimmunity and cancer. It exhibits chymotrypsin and trypsin like activity. Cathepsin G modulates neutrophil effector functions.
Cathepsin G has pro-apoptotic activity and can activate caspases in vitro.
Einheitendefinition
One unit will release one nanomole of p-nitroaniline per second from N-succinyl-Ala-Ala-Pro-Phe p-nitroanilide at pH 7.5 at 37 °C.
Physikalische Form
Lyophilized from 0.5 M pyridinium acetate, pH 5.3.
Inhibitor
Substrat
Produkt-Nr.
Beschreibung
Preisangaben
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
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