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Wichtige Dokumente
C4187
Cyanoborhydrid-Kupplungspuffer
Synonym(e):
Coupling buffer
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About This Item
UNSPSC-Code:
12161700
NACRES:
NA.56
Empfohlene Produkte
Form
liquid
Qualitätsniveau
Eignung der Reaktion
reagent type: reductant
Methode(n)
affinity chromatography: suitable
Anwendung(en)
life science and biopharma
Lagertemp.
2-8°C
Anwendung
Ein gebrauchsfertiges Supplement für die Kopplung von Amin-Liganden an Aldehydgruppen. Die Reaktion des Kupplungspuffers ist eine reduktive Aminierung der Schiffs-Basen-Zwischenstufe zu einer stabilen C−N-Bindung.
Cyanoborohydride Coupling Buffer has been used:
- in coupling reactions between amines and glutaraldehyde
- to reduce hydrazone bond to a stable hydrazide bond
- as a component in oligonucleotide reaction mixture for coverslips functionalization
Cyanoborohydride Coupling Buffer is used in affinity chromatography, protein chromatography, activated/functionalized matrices and synthetic reagents. Cyanoborohydride has been used to inform a safe and effective gene-transfer system targeting hepatocytes as well as to develop a method for targeted delivery of anticancer therapeutics to cancer cells in hypoxic areas.
Biochem./physiol. Wirkung
Cyanoborohydride Coupling Buffer is a reagent suitable for reductive amination processes, that contributes to transformation of simple alcohols into more complex amines. It is used in the conversion of Schiff base, by reducing it, to form a secondary amine without affecting aldehyde groups on the support.
Komponenten
0.02 M Natriumphosphat, pH 7.5, enthält 0.2 M Natriumchlorid und 3.0 g/L Natriumcyanoborhydrid
Signalwort
Warning
H-Sätze
Gefahreneinstufungen
Acute Tox. 4 Oral - Aquatic Chronic 2
Lagerklassenschlüssel
12 - Non Combustible Liquids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
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