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A3809
Asparaginase aus E. coli
lyophilized powder, 100-300 units/mg protein (biuret)
Synonym(e):
L-Asparagin-Amidohydrolase
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About This Item
Empfohlene Produkte
Form
lyophilized powder
Qualitätsniveau
Spezifische Aktivität
100-300 units/mg protein (biuret)
Zusammensetzung
Protein, ≥60%
Lagertemp.
2-8°C
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Allgemeine Beschreibung
Asparaginase is a bacterial enzyme and also a chemotherapeutic drug.
Anwendung
Asparaginase from Escherichia coli has been used:
- to compare the cytotoxic effect of L-asparaginase purified from Streptomyces brollosae NEAE-115
- as a standard in asparaginase assay to quantify asparaginase activities in various eel tissues
- to elicit amino acid deprivation
Biochem./physiol. Wirkung
Asparaginase (ASNase) products are usually obtained from Escherichia coli and Erwinia chrysanthemi. These enzymes can block the synthesis of protein in tumor cells. It shows high activity in the G1 phase of the cell cycle. It is capable of causing pancreatitis in leukemia patients.
Asparaginase is used in enzymatic assays and to convert asparagine to aspartic acid. Asparaginase is used to reduce the formation of acrylamide in starchy food products. It is also used as a chemotherapy agent for acute lymphoblastic leukemia . Product A3809 is from Escherichia coli and is provided as a lyophilized powder containing sodium chloride.
Asparaginase may cause cell death in leukemic cells by converting the necessary L-asparagine to aspartic acid and ammonia . Asparaginase is allosterically regulated and is crucial for proper cell functioning .
Einheitendefinition
1 U setzt 1.0 μmol Ammoniak aus L-Asparagin pro Minute frei bei pH 8.6 und 37 °C.
Physikalische Form
Lyophilisiertes Pulver, enthält Natriumchlorid
Angaben zur Herstellung
Chromatographisch aufgereinigt
Hinweis zur Analyse
Proteingehalt mittels Biuret-Reaktion bestimmt.
Signalwort
Warning
H-Sätze
Gefahreneinstufungen
Repr. 2 - Skin Sens. 1
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
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Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells
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Purification, characterization and immunogenicity assessment of glutaminase free L-asparaginase from Streptomyces brollosae NEAE-115
El-Naggar NEA, et al.
BMC Pharmacology & Toxicology, 19(1), 1-15 (2018)
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Metabolic reprogramming plays an essential role on lymphoma progression. Dysregulation of glutamine metabolism is implicated in natural-killer T-cell lymphoma (NKTCL) and tumor cell response to asparaginase-based anti-metabolic treatment. To understand the metabolomic alterations and determine the potential therapeutic target of
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