40584

Amentoflavon

≥98.0% (HPLC)

• Synonym(e): Didemethyl-ginkgetin, I3′,II8-Biapigenin, Tridemethylsciadopitysin
• Empirische Formel (Hill-System): C₃₀H₁₈O₁₀
• CAS-Nummer: 1617-53-4
• Molekulargewicht: 538.46
• Beilstein: 380244
• MDL-Nummer: MFCD00017470
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 57650005
• NACRES: NA.47

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98.0% (HPLC)
• Form: solid
• Anwendung(en): metabolomics; vitamins, nutraceuticals, and natural products
• Lagertemp.: 2-8°C
• SMILES String: Oc1ccc(cc1)C2=CC(=O)c3c(O)cc(O)c(c3O2)-c4cc(ccc4O)C5=CC(=O)c6c(O)cc(O)cc6O5
• InChI: 1S/C30H18O10/c31-15-4-1-13(2-5-15)24-12-23(38)29-21(36)10-20(35)27(30(29)40-24)17-7-14(3-6-18(17)33)25-11-22(37)28-19(34)8-16(32)9-26(28)39-25/h1-12,31-36H
• InChIKey: YUSWMAULDXZHPY-UHFFFAOYSA-N
• Angaben zum Gen: human ... GABRA1(2554)

Beschreibung

Allgemeine Beschreibung

Amentoflavone is a naturally occurring polyphenolic biflavonoid found in many plants. Structurally, it has an apigenin dimer which is linked by a C3′-C8′′ covalent bond.

Anwendung

Amentoflavone has been used:

• as a chemical inhibitor to determine the selective attenuation of p-Cresol glucuronidation in HepaRG cells
• as a reference standard for qualitative and quantitative analyses of phenolic compounds of Juniperus foetidissima Willd. and Juniperus sabina L. using reverse phase- high-performance liquid chromatography- diode array detector (RP-HPLC-DAD)
• as a reference standard to analyze and standardize the methanol extract process of Juniperus drupacea Labill. phenolic compounds using reverse phase- high-performance liquid chromatography - diode array detector (RP-HPLC-DAD)

Biochem./physiol. Wirkung

Biflavonoid mit entzündungshemmender, anti-viraler und chemopreventiver Wirkung. Es hemmt die Vaskularisation von Tumoren durch die Blockierung der Aktivität von angiogenen VEGFs. Blockiert die Induktion von COX-2 und reguliert PPAR-γ. Ein negativer Modulator ders GABA_A-Rezeptors an der Benzodiazepin-Bindungsstelle.

Amentoflavone has various pharmacological properties such as antioxidant, anti-diabetic, anti-tumor, anti-senescence, neuroprotective, and cardioprotective activities.

Verpackung

Bottomless glass bottle. Contents are inside inserted fused cone.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)