61767
Lektin aus Triticum vulgaris
lyophilized, ≥55% (GE), powder
Synonym(e):
WGA, Weizenkeim-Agglutinin
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About This Item
Empfohlene Produkte
Biologische Quelle
Triticum vulgaris
Form
powder
Qualität
lyophilized
Konzentration
≥55% (GE)
Methode(n)
agglutination assay: suitable using fresh human erythrocytes
Lagertemp.
2-8°C
Allgemeine Beschreibung
Molecular characteristics and specificity for sugar binding
Lectins are carbohydrate-binding proteins, omnipresent, found in fungi, plants and animals. The structure of lectin is diversely studied in plants and animals. The secondary structure of this protein is rich in β-strands and posses a carbohydrate binding sites on the surface.
Anwendung
Lectin from Triticum vulgaris has been used in bone resorption assays.
Wheat germ agglutinin conjugated to the outside surface of PLGA nanoparticles loaded with paclitaxel was used to target cancer cells that overexpress WGA-binding glycoproteins (Caco-2 and HT-29 cell lines). WGA-NP showed 50-60% greater endocytosis and intracellular retention of paclitaxel than unlabeled nanoparticles.
Biochem./physiol. Wirkung
Lectin is known to be useful in glycoconjugate characterizing, imaging and targeting. Its use in a microarray assay, enable efficient glycome profiling. This is because of its specific interaction with oligosaccharides, glycoproteins and glycolipids. In plants and fungi, lectin defends against pathogens/feeders. Lectin participates in host recognition and tissue adhesion, thereby aids in the pathogenesis of microorganism.
Sonstige Hinweise
Molecular characteristics and specificity for sugar binding
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
Eyeshields, Gloves, type N95 (US)
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