42579
4-Phenyl-1,2,4-triazolin-3,5-dion
for HPLC derivatization, LiChropur™, ≥98.0% (CHN)
Synonym(e):
4-Phenyl-3H-1,2,4-triazol-3,5(4H)-dion, PTAD
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About This Item
Empirische Formel (Hill-System):
C8H5N3O2
CAS-Nummer:
Molekulargewicht:
175.14
Beilstein:
141548
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
41116105
PubChem Substanz-ID:
NACRES:
NA.22
Empfohlene Produkte
Qualität
for HPLC derivatization
LiChropur™
Qualitätsniveau
Assay
≥98.0% (CHN)
Methode(n)
HPLC: suitable
mp (Schmelzpunkt)
165-170 °C (dec.) (lit.)
Lagertemp.
2-8°C
SMILES String
O=C1N=NC(=O)N1c2ccccc2
InChI
1S/C8H5N3O2/c12-7-9-10-8(13)11(7)6-4-2-1-3-5-6/h1-5H
InChIKey
ISULLEUFOQSBGY-UHFFFAOYSA-N
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Allgemeine Beschreibung
4-Phenyl-1,2,4-triazoline-3,5-dione, also known as Cookson reagent, is a strong dienophile, which gives a stable Diels-Alder adduct quantitatively within a short time and under mild conditions. It is commonly used as a protecting group of the diene moiety for the synthesis of vitamin D3 (VD3)-related compounds.
Anwendung
4-Phenyl-1,2,4-triazoline-3,5-dione may be used as a derivatizing reagent for the determination of trace levels of 25-hydroxyvitamin D and its C-3 epimer in biological samples and cholecalciferol (vitamin D3) in fortified infant formula, milk and milk powder using liquid chromatography–tandem mass spectrometry (LC–MS/MS)technique.
Rechtliche Hinweise
LiChropur is a trademark of Merck KGaA, Darmstadt, Germany
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
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Chromatographic separation of PTAD-derivatized 25-hydroxyvitamin D3 and its C-3 epimer from human serum and murine skin
Teegarden DM, et al.
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 991(1), 118-121 (2015)
Grant A Abernethy
Analytical and bioanalytical chemistry, 403(5), 1433-1440 (2012-03-24)
A method for analysing vitamin D(3) (VD3, cholecalciferol) has been established and validated. This method is rapid and cost effective and is intended for use in quality control in the manufacture of fortified infant formulae and milk powders. Milk or
A S Weiskopf et al.
Journal of mass spectrometry : JMS, 36(1), 71-78 (2001-02-17)
The structural specificity of vitamin D derivatization by PTAD (4-phenyl-1,2,4-triazoline-3,5-dione) was probed using synthetic analogues and ion trap mass spectrometry. EB 1089, a vitamin D(3) analogue which contains a second site for Diels--Alder cycloaddition on its side-chain, allowed the examination
Jiri Adamec et al.
Journal of separation science, 34(1), 11-20 (2010-12-21)
Simultaneous and accurate measurement of vitamin D and 25-hydroxyvitamin D in biological samples is a barrier limiting our ability to define "optimal" vitamin D status. Thus, our goal was to optimize conditions and evaluate an LC-MS method for simultaneous detection
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