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Sigma-Aldrich

α-Cyano-4-hydroxyzimtsäure

matrix substance for MALDI-MS, Ultra pure

Synonym(e):

α-CCA, α-CHCA, α-Cyano, 4-HCCA, ACCA

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About This Item

Lineare Formel:
HOC6H4CH=C(CN)CO2H
CAS-Nummer:
28166-41-8
Molekulargewicht:
189.17
Beilstein:
3271427
EG-Nummer:
248-879-1
MDL-Nummer:
MFCD00004204
UNSPSC-Code:
41116105
PubChem Substanz-ID:
329755873
NACRES:
NA.21

Qualität

matrix substance for MALDI-MS

Qualitätsniveau

100

Form

solid

chemische Klasse(n) des Analyten

glycans, peptides, proteins

Methode(n)

MALDI-MS: suitable

mp (Schmelzpunkt)

245-250 °C (lit.)
245-250 °C

Löslichkeit

methanol: 10 mg/mL, clear

Kationenspuren

Al: ≤1 mg/kg
Ba: ≤1 mg/kg
Ca: ≤1 mg/kg
Cd: ≤1 mg/kg
Co: ≤1 mg/kg
Cr: ≤1 mg/kg
Cu: ≤1 mg/kg
Fe: ≤1 mg/kg
K: ≤1 mg/kg
Li: ≤1 mg/kg
Mg: ≤1 mg/kg
Mn: ≤1 mg/kg
Na: ≤1 mg/kg
Ni: ≤1 mg/kg
Pb: ≤1 mg/kg
Sr: ≤1 mg/kg
Zn: ≤1 mg/kg

Lagertemp.

2-8°C

SMILES String

OC(=O)\C(=C\c1ccc(O)cc1)C#N

InChI

1S/C10H7NO3/c11-6-8(10(13)14)5-7-1-3-9(12)4-2-7/h1-5,12H,(H,13,14)/b8-5+

InChIKey

AFVLVVWMAFSXCK-VMPITWQZSA-N

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Allgemeine Beschreibung

α-Cyano-4-hydroxyzimtsäure (α-CHCA) wird häufig als Matrix verwendet, um die Ionisierung von Proteinen und Peptiden in einer Matrix-assistierten Laser-Desorption-Ionisierung (MALDI) mit kombiniertem Flugzeitanalysen(TOF)-Massenspektrometer (TOF, Time of Flight) zu ermöglichen.

Anwendung

Es wird als Matrix für einen verbesserten Nachweis des Verdaus von schwachen Proteinkonzentrationen in MALDI-TOF verwendet.

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Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

H-Sätze

H317

Gefahreneinstufungen

Skin Sens. 1B

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Choose from one of the most recent versions:

Analysenzertifikate (COA)

Lot/Batch Number
BCCF7066
BCCD4901
BCCB6242
BCCB4528
BCCB0620

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Die Dokumentenbibliothek aufrufen

Xiangping Zhu et al.
Journal of biomolecular techniques : JBT, 14(4), 298-307 (2004-01-13)
Alpha-cyano-4-hydroxycinnamic acid (alpha-CHCA) as a matrix facilitates the ionization of proteins and peptides in a matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) mass spectrometer. The matrix itself also ionizes and so do its sodium and potassium adducts. Matrix clusters and metal
Zhiqiang Zhao et al.
Cancer letters, 342(1), 150-158 (2013-09-10)
Monocarboxylate transporter isoform 1 (MCT1) is an important member of the proton-linked MCT family and has been reported in an array of human cancer cell lines and primary human tumors. MCT1 expression is associated with developing a new therapeutic approach
Kamil Karolczak et al.
International journal of pharmaceutics, 436(1-2), 508-518 (2012-06-23)
We hypothesized that BBB is impaired in rat model of streptozotocin-induced diabetes and can be sealed by poly(amido)amine dendrimers G4.0 (PAMAM G4), which reveal anti-glycation activity. The BBB permeabilization was monitored in rats with the 60-day streptozotocin-diabetes and non-diabetic animals
Rossella Gottardo et al.
Journal of mass spectrometry : JMS, 47(1), 141-146 (2012-01-28)
Since 2004, a number of herbal blends containing different synthetic compounds mimicking the pharmacological activity of cannabinoids and displaying a high toxicological potential have appeared in the market. Their availability is mainly based on the so-called "e-commerce", being sold as
Mohammadreza Shariatgorji et al.
Analytical chemistry, 84(16), 7152-7157 (2012-08-07)
D(4)-α-Cyano-4-hydroxycinnamic acid (D(4)-CHCA) has been synthesized for use as a matrix for matrix-assisted laser desorption ionization-mass spectrometry (MALDI-MS) and MALDI-MS imaging (MSI) of small molecule drugs and endogenous compounds. MALDI-MS analysis of small molecules has historically been hindered by interference
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