GF178

C1 Inhibitor

• Synonym(e): C1 Inh, C1 esterase inhibitor, Serpin G1
• UNSPSC-Code: 12352200
• eCl@ss: 32160405
• NACRES: NA.77

Eigenschaften

• product name: C1 Inhibitor,; Human Recombinant,
• Verunreinigungen: <0.1 μg/mg protein endotoxin (<1 EU/μg)
• Qualitätsniveau: 100
• UniProt-Hinterlegungsnummer: P05155
• Versandbedingung: dry ice

Beschreibung

Allgemeine Beschreibung

C1 Inhibitor is a member of the serpin family of structurally related proteins, and is the primary regulator of the immune complement system. C1 Inhibitor is a protease inhibitor that functions to inhibit the complement system in order to prevent over-activation or spontaneous activation. Inhibition is achieved by binding to and irreversibly inhibiting the C1r and C1s proteases of the C1 complex, which has the effect of shutting down all subsequent downstream events in the complement activation cascade. C1 inhibitor can also inhibit various other proteases, including Kallikrein, Factor XIa, and Factor XIIa.
Recombinant Human C1 Inhibitor is a highly glycosylated glycoprotein containing 445 amino acid residues (49.4kDa), corresponding to amino acids 56 – 500 of the C1 inhibitor precursor, and is fully functional in its ability to inhibit the C1 complex.

Product Source: Protein is expressed in E.coli.

Anwendung

Research Category
Stammzellforschung

Research Sub Category
Wachstumsfaktoren & -rezeptoren

Qualität

Measured by its ability to inhibit recombinant human complement component C1a cleavage of a colorimetric peptide substrate, N Carbobenzyloxy-Lys- ThioBenzyl ester (Z-K-SBzl). The expected IC50 is ≤ 2.6 nM.

Physikalische Form

Product is presented in 10mM Sodium Phosphate, pH 7.5 and is filtered through a 0.2 micron filter before lyophilization.

Lagerung und Haltbarkeit

Store at -20°C for up to 4 months from date of receipt Centrifuge the vial prior to opening.
Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein and store in working aliquots at -20°C.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3