8.55104

2-(4-Bromomethylphenoxy)ethyl polystyrene HL

Novabiochem^®

• UNSPSC-Code: 13111023
• NACRES: NA.22

Eigenschaften

• Qualitätsniveau: 200
• Produktlinie: Novabiochem^®
• Form: beads
• Eignung der Reaktion: reaction type: Fmoc solid-phase peptide synthesis
• Hersteller/Markenname: Novabiochem^®
• Anwendung(en): peptide synthesis
• Lagertemp.: 2-8°C

Beschreibung

Allgemeine Beschreibung

This versatile support is an excellent tool for the solid phase immobilization of carboxylic acids, amines and alcohols. Acids are attached by treating the resin with the appropriate DIPEA salt in DMF in the presence of CsI ^[1,2]. Reaction with aryl and alkyl amines provides resin-bound secondary amines. These can be readily acylated to give sulfonamides or anilides that can be cleaved with 95% TFA. Since this resin does not contain a benzylic ether linkage, it gives cleaner products than similar supports derived from Wang resin, free from impurities arising from breakdown of the linker. For examples using a similar resin, please see ^[1,2,3,4].

Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins

Literature references

^[1] J. W. Corbett, et al. (1997) Bioorg. Med. Chem. Lett., 7,1371.
^[2] G. A. Morales, et al. (1998) J. Org. Chem., 63,1172.
^[3] K. Ngu & D. V. Patel (1997) Tetrahedron Lett., 38, 973.
^[4] B. Raju & T. P. Kogan (1997) Tetrahedron Lett., 38, 4965.

Verlinkung

Replaces: 01-64-0400

Hinweis zur Analyse

Farbe (visuell): weiß bis gelb bis beige
Aussehen der Substanz (visuell): Kügelchen
Aufquellvolumen (in DMF): chargenspezifischer Wert
Beladung (Elementaranalyse aus Brom): 0.80 - 1.30 mmol/g
Die Polymermatrix ist Copoly (Styrol - 1 % DVB), 100 -200 mesh

Rechtliche Hinweise

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable