8.52417

Fmoc-Cys(Dpm)-OH

Novabiochem^®

• Synonym(e): N-α-Fmoc-S-diphenylmethyl-L-cysteine
• Empirische Formel (Hill-System): C₃₁H₂₇NO₄S
• CAS-Nummer: 247595-29-5
• Molekulargewicht: 509.62
• UNSPSC-Code: 12352209
• NACRES: NA.22

Eigenschaften

• Qualitätsniveau: 200
• Produktlinie: Novabiochem^®
• Form: powder
• Eignung der Reaktion: reaction type: Fmoc solid-phase peptide synthesis
• Hersteller/Markenname: Novabiochem^®
• Anwendung(en): peptide synthesis
• Funktionelle Gruppe: thiol
• Lagertemp.: 15-25°C
• InChI: 1S/C31H27NO4S/c33-30(34)28(20-37-29(21-11-3-1-4-12-21)22-13-5-2-6-14-22)32-31(35)36-19-27-25-17-9-7-15-23(25)24-16-8-10-18-26(24)27/h1-18,27-29H,19-20H2,(H,32,35)(H,33,34)/t28-/m0/s1
• InChIKey: IVPLDYIPIHKRET-NDEPHWFRSA-N

Beschreibung

Allgemeine Beschreibung

The Dpm group has increased stability compared to Trt, enabling selective removal of Mtt groups on the solid phase with dilute TFA without loss of Dpm groups. Furthermore, the Dpm group is removed by treatment with 95% TFA cleavage cocktails. Racemization during carboxyl activation is lower with this derivative than with Fmoc-Cys(Trt)-OH.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Fmoc SPPS of Cysteine-Containing Peptides

Literature references

^[1] H. Hibino, et al. (2014) J. Pept. Sci., 20, 30.
^[2] M. Góngora-Benítez, et al. (2012) Org.Lett., 14, 5472.

Hinweis zur Analyse

Colour (visual): white to off white
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.5 % (a/a)
Purity (HPLC): ≥ 98.0 % (a/a)
Purity (TLC(011A)): ≥ 98 %
Purity (TLC(0811)): ≥ 98 %
Solubility (1 mmole in 2 ml DMF): clearly soluble
Ethyl acetate (HS-GC): ≤ 0.5 %
Acetate (IC): ≤ 0.1 %

To see the solvent systems used for TLC of Novabiochem^® products please click here.

Rechtliche Hinweise

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable