8.52109

Fmoc-Gly-(Dmb)Gly-OH

Novabiochem^®

• Synonym(e): N-α-Fmoc-L-glycyl-N-α-(2, 4-dimethoxybenzyl)-glycine
• Empirische Formel (Hill-System): C₂₈H₂₈N₂O₇
• CAS-Nummer: 848861-65-4
• Molekulargewicht: 504.53
• UNSPSC-Code: 12352209

Eigenschaften

• Qualitätsniveau: 200
• Produktlinie: Novabiochem^®
• Assay: ≥90.0% (acidimetric); ≥95.0% (HPLC); ≥98% (TLC)
• Form: powder
• Eignung der Reaktion: reaction type: Fmoc solid-phase peptide synthesis
• Hersteller/Markenname: Novabiochem^®
• Anwendung(en): peptide synthesis
• Funktionelle Gruppe: Fmoc
• Lagertemp.: 2-8°C
• InChI: 1S/C28H28N2O7/c1-35-19-12-11-18(25(13-19)36-2)15-30(16-27(32)33)26(31)14-29-28(34)37-17-24-22-9-5-3-7-20(22)21-8-4-6-10-23(21)24/h3-13,24H,14-17H2,1-2H3,(H,29,34)(H,32,33)
• InChIKey: NJUCBQMDTSVIGD-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

The use of this derivative was found to be essential for the synthesis of peptides related to nucleolin ^[1]. Fmoc-Aaa-(Dmb)Gly-OH dipeptides offer the same benefits as pseudoproline dipeptides in Fmoc SPPS but for peptide sequences containing Gly. They are extremely easy to use. Standard coupling methods like PyBOP^®/DIPEA or DIPCDI/HOBt can be used for their introduction. Removal of the Dmb group and regeneration of the glycine residue occurs during the course of standard TFA-mediated cleavage reaction.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Overcoming Aggregation in Fmoc SPPS

Literature references

^[1] S. Zahariev, et al. (2005) J. Pept. Sci., 11, 17.

Verlinkung

Replaces: 04-12-1266

Hinweis zur Analyse

Farbe (visuell): weiß bis schwach gelb
Aussehen der Substanz (visuell): Pulver
Identität (IR): entspricht
Reinheit (DC(0811)): ≥ 98 %
Gehalt (HPLC, Fl.%): ≥ 95.0 % (a/a)
Gehalt (acidimetrisch): ≥ 90.0 %
Wasser (K. F.): ≤ 2.00 %
DC-Bedingungen gemäß den Angaben unseres Hauptkataloges

Rechtliche Hinweise

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

PyBOP is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable