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Key Documents

06-1425

Sigma-Aldrich

Anti-phospho-TAK1 (Ser412) Antibody

from rabbit, purified by affinity chromatography

Synonym(e):

Mitogen-activated protein kinase kinase kinase 7, Transforming growth factor-beta-activated kinase 1, TGF-beta-activated kinase 1

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About This Item

UNSPSC-Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Biologische Quelle

rabbit

Qualitätsniveau

100

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Aufgereinigt durch

affinity chromatography

Speziesreaktivität

human, mouse

Methode(n)

western blot: suitable

NCBI-Hinterlegungsnummer

NP_663306

UniProt-Hinterlegungsnummer

O43318

Versandbedingung

wet ice

Posttranslationale Modifikation Target

phosphorylation (pSer412)

Angaben zum Gen

human ... MAP3K7(6885)

Allgemeine Beschreibung

TAK1 MAPKKK is activated by TAB1 to transform growth factor-beta (TGF-beta) signaling. TAK1 can also associate with TAB1 to form a unique MAPKKK complex that is thought to activate AP-1 and the NFkappaB signaling pathways. TAK1 has been linked to both IL-1alpha and TNFalpha signaling and therefore may also be involved in the inflammatory response. Recent research has found that the TAK1-TAB1 complex may have anti-inflammatory effects by aiding stercurensin in regulating the NFκB-dependent inflammatory pathways.

Spezifität

This antibody recognizes TAK1 phosphorylated at Ser412.

Immunogen

Epitope: Phosphorylated Ser412
KLH-conjugated linear peptide corresponding to human TAK1 phosphorylated at Ser412.

Anwendung

Detect phospho-TAK1 (Ser412) using this Anti-phospho-TAK1 (Ser412) Antibody validated for use in WB.

Qualität

Evaluated by Western Blot in lambda phosphatase treated and untreated Murine RAW cell lysates.

Western Blot Analysis: 1 µg/mL of this antibody detected TAK1 on 10 µg of lambda phosphatase treated and untreated Murine RAW cell lysates.

Zielbeschreibung

~70 kDa observed

Hinweis zur Analyse

Control
Lambda phosphatase treated and untreated Murine RAW cell lysates

Sonstige Hinweise

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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Lagerklassenschlüssel

12 - Non Combustible Liquids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

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Chang-Soo Hong et al.
Frontiers in immunology, 10, 1760-1760 (2019-08-14)
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Viral G Jain et al.
Journal of immunology (Baltimore, Md. : 1950), 204(10), 2651-2660 (2020-04-03)
Preterm birth (PTB) is a major cause of neonatal mortality and morbidity, often triggered by chorioamnionitis or intrauterine inflammation (IUI) with or without infection. Recently, there has been a strong association of IL-1 with PTB. We hypothesized that IL-1R-associated kinase

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