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Merck

D-907

Supelco

Diazepam -Lösung

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Empirische Formel (Hill-System):
C16H13ClN2O
CAS-Nummer:
Molekulargewicht:
284.74
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
41116107
PubChem Substanz-ID:
NACRES:
NA.24

Qualität

certified reference material

Qualitätsniveau

Form

liquid

Leistungsmerkmale

Snap-N-Spike®/Snap-N-Shoot®

Verpackung

ampule of 1 mL

Hersteller/Markenname

Cerilliant®

drug control

Narcotic Licence Schedule B (Switzerland); psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)

Konzentration

1.0 mg/mL in methanol

Methode(n)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

Anwendung(en)

clinical testing

Format

single component solution

Lagertemp.

-10 to -25°C

SMILES String

CN1C(=O)CN=C(c2ccccc2)c3cc(Cl)ccc13

InChI

1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3

InChIKey

AAOVKJBEBIDNHE-UHFFFAOYSA-N

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Allgemeine Beschreibung

This Certified Spiking Solution® is suitable for testing diazepam by HPLC, GC/MS or LC-MS/MS methods in forensic analysis, clinical toxicology, urine drug testing, and cannabis potency or impurity profiling testing applications.

Diazepam is an anxiolytic benzodiazepine drug, commonly used to treat anxiety disorders, muscle spasms, and acute seizures among others.

Anwendung

The Certified Reference Material (CRM) in solution can also be used as follows:
  • Electrochemical determination of diazepam in serum, urine, and tablet formulations by a modified electrode based on fullerene-functionalized carbon nanotubes and ionic liquid (C60-CNTs/IL)
  • Differential voltametric analysis of diazepam in its tablet formulations and human urine samples using a bismuth-modified pre-treated pencil graphite electrode (BiPPGE)
  • Simultaneous quantitative determination of diazepam and flunitrazepam in alcoholic beverage samples by Direct-electron ionization-liquid chromatography-tandem mass spectrometry (EI-LC-MS/MS) method
  • Dispersive nanomaterial-ultrasound assisted-microextraction (DNUM) of diazepam and chlordiazepoxide from urine and plasma samples for their quantification by high-performance liquid chromatography -UV (HPLC-UV) detection
  • Multi-residue analysis of diazepam and its metabolites in human oral fluid samples by their solid-phase extraction followed by LC-MS/MS method-based determination

Leistungsmerkmale und Vorteile

  • Fully characterized under ISO/IEC 17025 and ISO 17034 accreditation
  • Accompanied with a comprehensive Certificate of Analysis (CoA) with data on stability, homogeneity, accuracy of concentration, uncertainty, and traceability
  • Rigorously tested through real-time stability studies to ensure accuracy and shelf life
  • Gravimetrically prepared using qualified precision balances to ensure minimal uncertainty
  • Flame sealed under argon into ampoules for long-term shelf life
  • Offered in a convenient, DEA-exempt format to improve laboratory efficiency

Rechtliche Hinweise

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Zielorgane

Eyes,Central nervous system

Lagerklassenschlüssel

3 - Flammable liquids

WGK

WGK 2

Flammpunkt (°F)

49.5 °F - closed cup

Flammpunkt (°C)

9.7 °C - closed cup


Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Electrochemical determination of diazepam in real samples based on fullerene-functionalized carbon nanotubes/ionic liquid nanocomposite
Rahimi-Nasrabadi M, et al.
Sensors and Actuators B, Chemical, 240, 125-131 (2017)
Voltammetric determination of diazepam using a bismuth modified pencil graphite electrode
Dehghanzade M and Alipour E
Analytical Methods : Advancing Methods and Applications, 8, 1995-2004 (2016)
Berend Malchow et al.
Journal of neural transmission (Vienna, Austria : 1996), 122(7), 1019-1033 (2014-10-14)
Hippocampus volumes have been shown to be decreased in patients with major depression, but volume measurements are inconsistent in patients with bipolar disorder. Both disorders are associated with deficits in hippocampus-mediated cognitive functions. However, the underlying pathophysiology is widely unknown.
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Epilepsia, 54(6), 1092-1098 (2013-04-05)
Prolonged febrile seizures (PFS) lasting ≥15 min have been associated with increased risk for epilepsy in later life. Initial treatment, mostly prehospital, aims to prevent its evolution to febrile status epilepticus (FSE) and reduce adverse outcome. Paucity of information is
Mai Anh Nguyen et al.
Journal of pharmaceutical sciences, 104(9), 3199-3207 (2015-05-20)
Quercetin is a plant flavonol that is available from both daily diet and nutraceuticals. To investigate the effect of acute and short-term intake of high-dose quercetin on CYP3A-mediated metabolism, 10 healthy volunteers received 7.5 mg oral midazolam without, with a

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