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C-016

(−)-Cotinine solution

Name: (−)-Cotinine solution
Brand: CERILLIAN

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

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About This Item

Empirische Formel (Hill-System):

C₁₀H₁₂N₂O

CAS-Nummer:

486-56-6

Molekulargewicht:

176.22

EG-Nummer:

200-659-6

MDL-Nummer:

MFCD00077696

UNSPSC-Code:

41116107

PubChem Substanz-ID:

329774764

NACRES:

NA.24

Qualität

certified reference material

Form

liquid

Leistungsmerkmale

SNAP-N-SPIKE^®, SNAP-N-SHOOT^®

Verpackung

ampule of 1 mL

Hersteller/Markenname

Cerilliant^®

Konzentration

1.0 mg/mL in methanol

Methode(n)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

Anwendung(en)

forensics and toxicology

Format

single component solution

Lagertemp.

−20°C

SMILES String

CN1C(CCC1=O)c2cccnc2

InChI

1S/C10H12N2O/c1-12-9(4-5-10(12)13)8-3-2-6-11-7-8/h2-3,6-7,9H,4-5H2,1H3/t9-/m0/s1

InChIKey

UIKROCXWUNQSPJ-VIFPVBQESA-N

Allgemeine Beschreibung

An analytical reference standard of the major urinary metabolite of nicotine. Not only is cotinine a biomarker for users of nicotine products including cigarettes, cigars, and snuff, but it′s also an alkaloid found in tobacco. Suitable uses for this analytical reference standard include as a starting material in calibrators and controls for GC/MS and LC/MS applications in nicotine testing methods or clinical and diagnostic testing of nicotine biomarkers.

Anwendung

Biomarker Analysis in Medical Research: Examination of prolidase as a potential indicator of inflammation associated with cigarette smoking, where (-)-cotinine is a key biomarker, enhances understanding of chronic inflammation and its biochemical pathways in smokers (Yıldırım & Kulaksızoglu, 2024).

Comparative Toxicology Studies: Research evaluating blood biomarkers of inflammation in users of heated tobacco products compares these markers, including (-)-cotinine, with non-smoking individuals, offering insights into the inflammatory effects of new tobacco product usage on health (Świątkowska et al., 2024).

Rechtliche Hinweise

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Signalwort

Danger

H-Sätze

H225,H301 + H311 + H331,H370

P-Sätze

P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311

Gefahreneinstufungen

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Zielorgane

Eyes

Lagerklassenschlüssel

3 - Flammable liquids

WGK

WGK 2

Flammpunkt (°F)

49.5 °F - closed cup

Flammpunkt (°C)

9.7 °C - closed cup

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Cotinine analytical workshop report: consideration of analytical methods for determining cotinine in human body fluids as a measure of passive exposure to tobacco smoke.

R R Watts et al.

Environmental health perspectives, 84, 173-182 (1990-03-01)

A two-day technical workshop was convened November 10-11, 1986, to discuss analytical approaches for determining trace amounts of cotinine in human body fluids resulting from passive exposure to environmental tobacco smoke (ETS). The workshop, jointly sponsored by the U.S. Environmental

US prevalence and trends in tobacco smoke exposure among children and adolescents with asthma.

Brian K Kit et al.

Pediatrics, 131(3), 407-414 (2013-02-13)

To examine exposure to tobacco smoke products (TSPs), environmental tobacco smoke (ETS), and in-home smoke among youth with asthma in the United States. Nationally representative, cross-sectional data from 2250 youth aged 4 to 19 years with current asthma in the

Maternal smoking during pregnancy and fetal biometry: the INMA Mother and Child Cohort Study.

Carmen Iñiguez et al.

American journal of epidemiology, 178(7), 1067-1075 (2013-09-07)

In utero tobacco exposure has been associated with fetal growth restriction, but uncertainty remains about critical windows of exposure and specific effects on body segments. In the present study, we aimed to examine the association of maternal smoking with fetal

Urinary cotinine as a tobacco-smoke exposure index: a minireview.

V Haufroid et al.

International archives of occupational and environmental health, 71(3), 162-168 (1998-05-20)

A minireview is presented concerning the use of cotinine as a tobacco-smoke exposure index. First, general considerations about methods for the determination of urinary cotinine are presented. Besides pure analytical aspects, this minireview considers major problems encountered in the establishment

Association of time-location patterns with urinary cotinine among asthmatic children under household environmental tobacco smoke exposure.

Kuan-Yen Tung et al.

Environmental research, 124, 7-12 (2013-04-30)

Environmental tobacco smoke (ETS) is a hazardous component of indoor air, and may increase the risk of respiratory diseases, atherosclerosis and otitis media in children. In this study, we explored the relationship between time inside the house, ETS exposure and

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