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N-077

Supelco

(S)-N-Nitrosoanabasine (NAB) solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

Synonym(e):

NAB, NAB -Lösung

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About This Item

Empirische Formel (Hill-System):
C10H13N3O
CAS-Nummer:
1133-64-8
Molekulargewicht:
191.23
EG-Nummer:
200-659-6
MDL-Nummer:
MFCD01669936
UNSPSC-Code:
41116107
PubChem Substanz-ID:
329818460
NACRES:
NA.24

Qualität

certified reference material

Qualitätsniveau

300

Form

liquid

Leistungsmerkmale

Snap-N-Spike®/Snap-N-Shoot®

Verpackung

ampule of 1 mL

Hersteller/Markenname

Cerilliant®

Konzentration

1.0 mg/mL in methanol

Methode(n)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

Anwendung(en)

forensics and toxicology

Format

single component solution

Lagertemp.

−20°C

SMILES String

O=NN1CCCC[C@H]1c2cccnc2

InChI

1S/C10H13N3O/c14-12-13-7-2-1-5-10(13)9-4-3-6-11-8-9/h3-4,6,8,10H,1-2,5,7H2/t10-/m0/s1

InChIKey

BXYPVKMROLGXJI-JTQLQIEISA-N

Allgemeine Beschreibung

N-Nitrosoanabasine or NAB is a potent carcinogen and biomarker of exposure to cigarette smoke. It′s found in a variety of tobacco products including chewing tobacco and snuff. Certified Spiking Solutions® are suitable for use in LC-MS/MS or GC/MS methods for nicotine testing, environmental monitoring, or clinical and diagnostic testing of nicotine biomarkers.

Anwendung

  • Inhibitory effects in toxicological studies: (S)-N-Nitrosoanabasine (NAB) has been used in research to investigate its inhibitory effects on the metabolism of the tobacco-specific nitrosamine, NNK, by cytochrome P450 2A13, highlighting its utility in carcinogenicity studies and its role as a research chemical in understanding biochemical pathways involved in cancer (Liu et al., 2016).

Rechtliche Hinweise

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTIONS is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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Signalwort

Danger

Gefahreneinstufungen

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Zielorgane

Eyes

Lagerklassenschlüssel

3 - Flammable liquids

WGK

WGK 1

Flammpunkt (°F)

49.5 °F - closed cup

Flammpunkt (°C)

9.7 °C - closed cup

Zulassungslistungen

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EU REACH Annex XVII (Restriction List)

CAS No.

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Analysenzertifikate (COA)

Lot/Batch Number

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Die Dokumentenbibliothek aufrufen

A M Idris et al.
Carcinogenesis, 12(6), 1115-1118 (1991-06-01)
The aim of these studies was to determine the levels of carcinogenic tobacco specific nitrosamines (TSNA) in Sudanese oral snuff (toombak) as recent retrospective epidemiological studies suggested an association between the use of toombak and subsequent development of oral cancer.
G Andersson et al.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 23(4), 161-167 (1994-04-01)
The purpose of this study was to investigate the uptake and metabolism of nicotine by smokeless (oral) tobacco users and to find out if the less pronounced clinical changes in the oral mucosa in users of portion-bag packed oral moist
Irina Stepanov et al.
Journal of agricultural and food chemistry, 50(10), 2793-2797 (2002-05-02)
Tobacco-specific nitrosamines (TSNA) are among the most important and abundant strongly carcinogenic agents in unburned tobacco. It has been established that 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces lung tumors in rodents independent of the route of administration. N'-Nitrosonornicotine (NNN) causes tumors of the
N'-Nitrosoanabasine (NAB).
IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans, 37, 225-231 (1985-09-01)
B Hasséus et al.
European journal of oral sciences, 105(1), 45-51 (1997-02-01)
Smokeless tobacco (ST) is known to adversely effect the oral mucosa, but knowledge about the influence on immune defence is limited. Few studies have investigated the effect of ST on the local immune response. In the present study, we have
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Artikel

LC/MS Analysis of Nicotine and Metabolites on Kromasil® Eternity™ C18 (Analyte Set 1)

Separation of (+)-Anabasine hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material; S(−)-Nicotine solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material; (S)-N-Nitrosoanabasine (NAB) solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material

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