910015

17-Azido-3,6,9,12,15-pentaoxaheptadecanoic acid

≥95%

• Synonym(e): Azido-PEG₅-CH₂CO₂H, Azido-PEG₅-acid, N₃-PEG₅-CH₂COOH
• Empirische Formel (Hill-System): C₁₂H₂₃N₃O₇
• CAS-Nummer: 217180-81-9
• Molekulargewicht: 321.33
• MDL-Nummer: MFCD31561141
• UNSPSC-Code: 12352106

Eigenschaften

• Assay: ≥95%
• Form: (Liquid or Semi-solid or Paste or Solid)
• Eignung der Reaktion: reaction type: click chemistry; reagent type: cross-linking reagent
• Funktionelle Gruppe: azide; carboxylic acid
• Lagertemp.: 2-8°C
• SMILES String: OC(COCCOCCOCCOCCOCCN=[N+]=[N-])=O

Beschreibung

Anwendung

This heterobifunctional, PEGylated crosslinker 17-Azido-3,6,9,12,15-pentaoxaheptadecanoic acid features a carboxyl group at one end and azide at the other. The hydrophillic PEG linker facilitates solubility in biological applications. This azido-PEG₅-acid linker can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

Sonstige Hinweise

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Rechtliche Hinweise

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable