902527

Amino-PEG5-t-butyl ester

≥95%

• Synonym(e): tert-Butyl-1-amino-3,6,9,12,15-pentaoxaoctadecan-18-oate, H₂N-PEG₅-CH₂CH₂COOtBu
• Empirische Formel (Hill-System): C₁₇H₃₅NO₇
• CAS-Nummer: 1446282-18-3
• Molekulargewicht: 365.46
• MDL-Nummer: MFCD25424125
• UNSPSC-Code: 51171641

Eigenschaften

• Assay: ≥95%
• Form: liquid
• Eignung der Reaktion: reagent type: cross-linking reagent
• Brechungsindex: n/D 1.4534
• Dichte: 1.4690 g/mL
• Funktionelle Gruppe: amine; ester
• Lagertemp.: −20°C
• SMILES String: NCCOCCOCCOCCOCCOCCC(OC(C)(C)C)=O

Beschreibung

Anwendung

This heterobifunctional, PEGylated crosslinker features an amino group at one end and t-butyl-protected carboxyl group at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Amino-PEG5-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

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Rechtliche Hinweise

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 3
• Flammpunkt (°F): No data available
• Flammpunkt (°C): No data available