900913

Tetrazine-PEG5-NHS ester

≥95%

• Synonym(e): Tz-PEG5-NHS
• Empirische Formel (Hill-System): C₂₇H₃₆N₆O₁₀
• CAS-Nummer: 1682653-80-0
• Molekulargewicht: 604.61
• MDL-Nummer: MFCD28505547
• UNSPSC-Code: 12352108
• NACRES: NA.22

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥95%
• Form: powder or crystals
• Eignung der Reaktion: reaction type: click chemistry; reagent type: linker
• Funktionelle Gruppe: NHS ester
• Lagertemp.: −20°C
• SMILES String: O=C(NCC1=CC=C(C2=NN=CN=N2)C=C1)CCOCCOCCOCCOCCOCCC(ON3C(CCC3=O)=O)=O

Beschreibung

Allgemeine Beschreibung

Tetrazine-PEG5-NHS ester has an N-hydroxysuccinimide (NHS) ester that can be reacted with primary amines and tetrazine, which is reactive to trans-cyclooctenes. Hydrogen substituted tetrazines demonstrate exceptionally fast kinetics, generally at least 10-fold faster compared to methyl substituted tetrazines. The aqueous solubility of this reagent is substantially enhanced by a hydrophilic polyethylene glycol (PEG) spacer arm.

Anwendung

Tetrazine-PEG5-NHS ester (Tz-PEG₅-NHS) can be used in click chemistry applications such as the preparation of chitosan-polyacrylamide microspheres utilizing selective tetrazine-trans-cyclooctene (Tz-TCO) ligation and the construction of copper-64 radiolabeled antibody by the click reaction.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable