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Merck

717142

Sigma-Aldrich

Poly(ethylenglykol)dithiol

average Mn 1,000, thiol

Synonym(e):

PEG-dithiol

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About This Item

Lineare Formel:
HSCH2CH2(OCH2CH2)nSH
UNSPSC-Code:
12162002
NACRES:
NA.23

Produktbezeichnung

Poly(ethylenglykol)dithiol, average Mn 1,000

Form

solid

Qualitätsniveau

Mol-Gew.

average Mn 1,000

Eignung der Reaktion

reagent type: cross-linking reagent
reactivity: thiol reactive

mp (Schmelzpunkt)

29-33 °C

Ω-Ende

thiol

α-Ende

thiol

Polymerarchitektur

shape: linear
functionality: homobifunctional

Lagertemp.

2-8°C

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Anwendung

Thiol functionalized nanoparticles may be used in mucoadhesive drug delivery, synthesis of dithiol terminated amphiphilic diblock copolymer, Bidentate dithiol-poly(ethylene glycol)-poly(d,l-lactide) (SH2-PEG-PDLLA). Gold nanoparticles may be easily functionalized with PEG dithiols by simple ligand exchange.

Sonstige Hinweise

Molecular weight: Mn 900-1,100

Piktogramme

Exclamation mark

Signalwort

Warning

Gefahreneinstufungen

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


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Nadeau J
Introduction to Experimental Biophysics: Biological Methods for Physical Scientists null
Jian Yang et al.
Biomacromolecules, 15(4), 1346-1354 (2014-03-13)
Thiol-modified nanoparticles have potential applications in mucoadhesive drug delivery and have been examined in this regard for topical ocular delivery. In this paper we provide a simple method for the synthesis of a dithiol terminated amphiphilic diblock copolymer. Bidentate dithiol-poly(ethylene

Artikel

The use of hydrogel-based biomaterials for the delivery and recruitment of cells to promote tissue regeneration in the body is of growing interest. This article discussed the application of hydrogels in cell delivery and tissue regeneration.

Progress in biotechnology fields such as tissue engineering and drug delivery is accompanied by an increasing demand for diverse functional biomaterials. One class of biomaterials that has been the subject of intense research interest is hydrogels, because they closely mimic the natural environment of cells, both chemically and physically and therefore can be used as support to grow cells. This article specifically discusses poly(ethylene glycol) (PEG) hydrogels, which are good for biological applications because they do not generally elicit an immune response. PEGs offer a readily available, easy to modify polymer for widespread use in hydrogel fabrication, including 2D and 3D scaffold for tissue culture. The degradable linkages also enable a variety of applications for release of therapeutic agents.

Devising biomaterial scaffolds that are capable of recapitulating critical aspects of the complex extracellular nature of living tissues in a threedimensional (3D) fashion is a challenging requirement in the field of tissue engineering and regenerative medicine.

Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..

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