47619

Fmoc-Ser(tBu)-OH

≥98.0% (HPLC), for peptide synthesis

• Synonym(e): Fmoc-O-tert.-butyl-L-serin
• Empirische Formel (Hill-System): C₂₂H₂₅NO₅
• CAS-Nummer: 71989-33-8
• Molekulargewicht: 383.44
• Beilstein: 3632013
• EG-Nummer: 276-260-6
• MDL-Nummer: MFCD00037127
• UNSPSC-Code: 12352209
• eCl@ss: 32160406
• PubChem Substanz-ID: 57651041
• NACRES: NA.26

Eigenschaften

• product name: Fmoc-Ser(tBu)-OH, ≥98.0% (HPLC)
• Assay: ≥98.0% (HPLC)
• Form: powder
• Optische Aktivität: [α]20/D +25.5±1°, c = 1% in ethyl acetate
• Eignung der Reaktion: reaction type: Fmoc solid-phase peptide synthesis
• Anwendung(en): peptide synthesis
• Funktionelle Gruppe: Fmoc
• Lagertemp.: 2-8°C
• SMILES String: CC(C)(C)OC[C@H](NC(=O)OCC1c2ccccc2-c3ccccc13)C(O)=O
• InChI: 1S/C22H25NO5/c1-22(2,3)28-13-19(20(24)25)23-21(26)27-12-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,18-19H,12-13H2,1-3H3,(H,23,26)(H,24,25)/t19-/m0/s1
• InChIKey: REITVGIIZHFVGU-IBGZPJMESA-N

Beschreibung

Anwendung

Fmoc-Ser(tBu)-OH is an N-terminal protected reagent used in the peptide synthesis. Some of the reported examples are:

• Total synthesis of an antibiotic, daptomycin, by cyclization via a chemoselective serine ligation.
• Preparation of MUC1, a T-cell helper peptide, using iterative pentafluorophenyl ester-mediated fragment condensations.
• Linear solid-phase peptide synthesis of ubiquitin and diubiquitin.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)