457701

(S)-Tetrahydro-1-methyl-3,3-diphenyl-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaborol -Lösung

1 M in toluene

• Synonym(e): α,α-Diphenyl-L-prolinolmethylboronsäure-cycl-amidester, (S)-(−)-2-Methyl-CBS-oxazaborolidin, (S)-1-Methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2c][1,3,2]oxazaborol, (S)-3,3-Diphenyl-1-methyltetrahydro-3H-pyrrolo[1,2-c][1,3,2]oxazaborol
• Empirische Formel (Hill-System): C₁₈H₂₀BNO
• CAS-Nummer: 112022-81-8
• Molekulargewicht: 277.17
• MDL-Nummer: MFCD00078439
• UNSPSC-Code: 12352005
• PubChem Substanz-ID: 24869386
• NACRES: NA.22

Eigenschaften

• Qualitätsniveau: 100
• Konzentration: 1 M in toluene
• bp: 111 °C
• Dichte: 0.929 g/mL at 25 °C
• Funktionelle Gruppe: phenyl
• Lagertemp.: room temp
• SMILES String: CB1OC([C@@H]2CCCN12)(c3ccccc3)c4ccccc4
• InChI: 1S/C18H20BNO/c1-19-20-14-8-13-17(20)18(21-19,15-9-4-2-5-10-15)16-11-6-3-7-12-16/h2-7,9-12,17H,8,13-14H2,1H3/t17-/m0/s1
• InChIKey: VMKAFJQFKBASMU-KRWDZBQOSA-N

Beschreibung

Anwendung

Catalyst employed in an enantioselective synthesis of (S)-2-amino-1-phenylethanol.

Excellent catalyst for asymmetric reductions.

The CBS (Corey-Bakshi-Shibata) oxazaborolidine catalyst has been used in the asymmetric reduction of prochiral ketones. Other applications include the enantioselective synthesis of α-hydroxy acids, α-amino acids, C₂-symmetrical ferrocenyl diols, and propargyl alcohols.

CBS Catalysts for Asymmetric Reduction and Asymmetric Synthesis

(S)-(-)-2-Methyl-CBS-oxazaborolidine solution [1M in toluene] may be used as a catalyst in the multi-step synthesis of (-)-diospongin A.
It may also be used in the preparation of:

• (1S)-2-azido-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)ethanol
• (R)-α-deuteriobenzyl alcohol
• (R)-2-(1-hydroxyethyl)benzo[b]thiophene

Sonstige Hinweise

Precipitate may form in storage, but does not affect product quality. Gently heat product to 80-90 °C under an inert atmosphere to redissolve solids.

Sicherheitshinweise

• Piktogramme: GHS02,GHS08,GHS05,GHS07
• Signalwort: Danger
• H-Sätze: H225,H302,H304,H315,H318,H336,H361d,H373,H412
• P-Sätze: P201 - P210 - P273 - P280 - P301 + P310 + P331 - P305 + P351 + P338 + P310
• Gefahreneinstufungen: Acute Tox. 4 Oral - Aquatic Chronic 3 - Asp. Tox. 1 - Eye Dam. 1 - Flam. Liq. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 2 - STOT SE 3
• Zielorgane: Central nervous system
• Lagerklassenschlüssel: 3 - Flammable liquids
• WGK: WGK 3
• Flammpunkt (°F): 39.2 °F - closed cup
• Flammpunkt (°C): 4 °C - closed cup
• Persönliche Schutzausrüstung: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter