362654

2-Fluor-5-nitrobenzoesäure

98%

• Lineare Formel: FC₆H₃(NO₂)CO₂H
• CAS-Nummer: 7304-32-7
• Molekulargewicht: 185.11
• MDL-Nummer: MFCD00134238
• UNSPSC-Code: 12352100
• PubChem Substanz-ID: 24862326
• NACRES: NA.22

Eigenschaften

• Qualitätsniveau: 100
• Assay: 98%
• Form: solid
• mp (Schmelzpunkt): 142-144 °C (lit.)
• Funktionelle Gruppe: carboxylic acid; fluoro; nitro
• SMILES String: OC(=O)c1cc(ccc1F)[N+]([O-])=O
• InChI: 1S/C7H4FNO4/c8-6-2-1-4(9(12)13)3-5(6)7(10)11/h1-3H,(H,10,11)
• InChIKey: ICXSHFWYCHJILC-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

2-Fluoro-5-nitrobenzoic acid is reported to react with an aldehyde, isonitrile and a primary amine tethered to a Boc-protected internal amino or hydroxyl nucleophile, to afford the Ugi product.

Anwendung

2-Fluoro-5-nitrobenzoic acid may be used in the synthesis of:

• dibenz[b,f]oxazepin-11(10H)-ones, via the nucleophilic aromatic substitution (S_NAr) of fluorine in 2-fluoro-5-nitrobenzoic acid with the OH of various 2-aminophenols on solid support
• synthesis of substituted dibenzazocines on solid support, via S_NAr of fluorine in 2-fluoro-5-nitrobenzoic acid with the OH function of the immobilized polysubstituted phenols
• in the synthesis of oxazepines

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315,H319,H335
• P-Sätze: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves