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Sigma-Aldrich

Phenethylisothiocyanat

99%

Synonym(e):

(2-Phenylethyl)-isothiocyanat

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About This Item

Lineare Formel:
C6H5CH2CH2NCS
CAS-Nummer:
2257-09-2
Molekulargewicht:
163.24
Beilstein:
2084162
EG-Nummer:
218-855-5
MDL-Nummer:
MFCD00004821
UNSPSC-Code:
12352100
PubChem Substanz-ID:
24855324
NACRES:
NA.22

Assay

99%

Form

liquid

Brechungsindex

n20/D 1.5888 (lit.)

bp

139-140 °C/11 mmHg (lit.)

Dichte

1.094 g/mL at 25 °C (lit.)

Lagertemp.

2-8°C

SMILES String

S=C=NCCc1ccccc1

InChI

1S/C9H9NS/c11-8-10-7-6-9-4-2-1-3-5-9/h1-5H,6-7H2

InChIKey

IZJDOKYDEWTZSO-UHFFFAOYSA-N

Angaben zum Gen

human ... CYP1A2(1544)

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Allgemeine Beschreibung

Phenethyl isothiocyanate is a naturally occurring isothiocyanate in cruciferous vegetables. Phenethyl isothiocyanate is a chemopreventive agent. It inhibits cancer cell growth by arresting the cell cycle and inducing apoptosis in various human cancer cell models.

Piktogramme

Health hazardExclamation mark
GHS08,GHS07

Signalwort

Danger

Gefahreneinstufungen

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 3

Flammpunkt (°F)

235.4 °F - closed cup

Flammpunkt (°C)

113 °C - closed cup

Persönliche Schutzausrüstung

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Analysenzertifikate (COA)

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Marilyn E Morris et al.
The AAPS journal, 16(4), 705-713 (2014-05-14)
Phenethyl isothiocyanate (PEITC)-a naturally occurring isothiocyanate in cruciferous vegetables-has been extensively studied as a chemopreventive agent in several preclinical species and in humans. Pharmacokinetic features of unchanged PEITC are (I) linear and first-order absorption, (II) high protein binding and capacity-limited
Yating Wang et al.
Molecular medicine reports, 10(1), 543-549 (2014-05-03)
Phenethyl isothiocyanate (PEITC), a potential cancer chemopreventive constituent of cruciferous vegetables, including watercress, has been reported to inhibit cancer cell growth by arresting the cell cycle and inducing apoptosis in various human cancer cell models. However, the role of PEITC
Ka Lung Cheung et al.
The AAPS journal, 10(2), 277-281 (2008-05-14)
Phenethyl isothiocyanate (PEITC), an isothiocyanate abundantly found in cruciferous vegetables have been shown to induce apoptosis through MAPK pathway in prostate and colon cancer cells. In the present study, we investigate the effect of PEITC on cell cycle regulation of
Jianzhong Zhu et al.
Journal of immunology (Baltimore, Md. : 1950), 190(8), 4400-4407 (2013-03-20)
Naturally occurring isothiocyanates (ITCs) from cruciferous vegetables are widely studied for their cancer chemopreventive effects. In this study, we investigated the effects of ITCs on TLR signaling, and found that the two most promising ITCs, phenethyl ITCs (PEITC) and D,L-sulforaphane
Parul Gupta et al.
BMC medicine, 10, 80-80 (2012-07-25)
HER2 is an oncogene, expression of which leads to poor prognosis in 30% of breast cancer patients. Although trastuzumab is apparently an effective therapy against HER2-positive tumors, its systemic toxicity and resistance in the majority of patients restricts its applicability.
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