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Analytical methodologies for the determination of omeprazole: an overview.

Journal of pharmaceutical and biomedical analysis (2007-05-29)
M Espinosa Bosch, A J Ruiz Sánchez, F Sánchez Rojas, C Bosch Ojeda
ABSTRACT

Omeprazole, a gastric acid pump inhibitor, dose-dependently controls gastric acid secretion; the drug has greater antisecretory activity than histamine H(2)-receptor antagonists. Omeprazole has been determined in formulations and biological fluids by a variety of methods such as spectrophotometry, high-performance liquid chromatography with ultraviolet detection and liquid chromatography coupled with tandem mass spectrometry. The overview includes the most relevant analytical methodologies used in its determination since the origin still today.

MATERIALI
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Marchio
Descrizione del prodotto

Sigma-Aldrich
Omeprazolo, solid
USP
Omeprazolo, United States Pharmacopeia (USP) Reference Standard
Supelco
Omeprazolo, Pharmaceutical Secondary Standard; Certified Reference Material
Supelco
Omeprazolo, analytical standard
Omeprazolo, European Pharmacopoeia (EP) Reference Standard
Omeprazolo, European Pharmacopoeia (EP) Reference Standard