- Lithiation directed by amino alkoxides. Application to the synthesis of new disubstituted dihydrodipyridopyrazines.
Lithiation directed by amino alkoxides. Application to the synthesis of new disubstituted dihydrodipyridopyrazines.
The synthesis of new 4,6-disubstituted dihydrodipyridopyrazines starting from corresponding carboxaldehydes via lithiation directed by alpha-amino alkoxides is described. The N,N,N'-trimethylethylenediamine was used as amine component for in situ formation of the alpha-amino alkoxides. After optimization, this reaction allowed easy access to new interesting starting materials for further applications by palladium-catalyzed reactions.