1353500

Isotretinoin

United States Pharmacopeia (USP) Reference Standard

• Sinonimo/i: 13-cis-Retinoic acid, 13-cis-Vitamin A acid, Isotretinoin
• Formula empirica (notazione di Hill): C₂₀H₂₈O₂
• Numero CAS: 4759-48-2
• Peso molecolare: 300.44
• Numero MDL: MFCD00079542
• Codice UNSPSC: 41116107
• ID PubChem: 329750208
• NACRES: NA.24

Proprietà

• Grado: pharmaceutical primary standard
• Famiglia di API: isotretinoin
• Produttore/marchio commerciale: USP
• Punto di fusione: 172-175 °C (lit.)
• applicazioni: pharmaceutical (small molecule)
• Formato: neat
• Stringa SMILE: [H]\C(C(O)=O)=C(C)\C=C\C=C(C)\C=C\C1=C(C)CCCC1(C)C
• InChI: 1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14-; SHGAZHPCJJPHSC-XFYACQKRSA-N
• Informazioni sul gene: human ... RARA(5914) , RARB(5915) , RARG(5916)

Descrizione

Descrizione generale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Applicazioni

Isotretinoin USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

• Isotretinoin Capsules
• Tretinoin

Azioni biochim/fisiol

13-cis-Retinoic acid (RA) has anti-inflammatory and anti-tumor action. The action of RA is mediated through RAR-β and RAR-α receptors. RA attenuates iNOS expression and activity in cytokine-stimulated murine mesangial cells. It induces mitochondrial membrane permeability transition, observed as swelling and as a decrease in membrane potential, and stimulates the release of cytochrome c implicating mechanisms through the apoptosis pathway. These activities are reversed by EGTA and cyclosporin A. RA also increases MMP-1 protein expression partially via increased transcription.

Risultati analitici

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Altre note

Sales restrictions may apply.

Informazioni sulla sicurezza

• Pittogrammi: GHS08,GHS07
• Avvertenze: Danger
• Indicazioni di pericolo: H315,H319,H335,H360FD
• Consigli di prudenza: P202 - P261 - P264 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Classi di pericolo: Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3
• Organi bersaglio: Respiratory system
• Codice della classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable