569232-U

Discovery^® C18 (5 µm) HPLC Columns

L × I.D. 12.5 cm × 4.6 mm, HPLC Column

• Sinonimo/i: Discovery RP18 HPLC Column
• Codice UNSPSC: 41115700
• eCl@ss: 32110501
• NACRES: SB.52

Proprietà

• Nome del prodotto: Colonna HPLC Discovery^® C18, 5 μm particle size, L × I.D. 12.5 cm × 4.6 mm
• Materiali: stainless steel column
• Livello qualitativo: 100
• agenzia: suitable for USP L1
• Nome Commerciale: Discovery^®
• Caratteristiche: endcapped
• Produttore/marchio commerciale: Discovery^®
• Confezionamento: 1 ea of
• Grado di funzionalizzazione: 12% Carbon loading
• Parametri: ≤70 °C temp. range; 400 bar pressure (5801 psi)
• tecniche: HPLC: suitable; LC/MS: suitable
• Lungh. × D.I.: 12.5 cm × 4.6 mm
• Area superficiale: 300 m²/g
• Copertura della superficie: 3 μmol/m²
• Impurezze: <10 ppm metals
• Matrice: silica gel, high purity, spherical particle platform; fully porous particle
• Gruppo funzionale matrice: C18 (octadecyl) phase
• Dimensione particelle: 5 μm
• Dimensione pori: 180 Å
• Intervallo di pH d’impiego: 2-8
• applicazioni: food and beverages
• Tecnica di separazione: reversed phase

Descrizione

Descrizione generale

Usare Discovery® C18 per qualsiasi metodo che specifichi una colonna C18. L′eccezionale profilo dei picchi, la riproducibilità e la stabilità ne fanno la colonna di elezione per tutti i metodi C18, da quelli di routine a quelli più critici.

Applicazioni

• Rat Pharmacokinetics and In Vitro Metabolite Identification of KM-819, a Parkinson′s Disease Candidate, Using LC-MS/MS and LC-HRMS.: This study underscores the utility of theDiscovery^® C18 HPLC Column in pharmacokinetic profiling and metabolite identification of a novel therapeutic agent, demonstrating its critical role in the development of Parkinson′s disease treatments (Choi et al., 2024).


• Determination of 2,4-dimethylhydroxybenzene by chromatographic methods in forensic toxicological research of biological material.: Highlights the application of the Discovery^® C18 HPLC Column in forensic toxicology, enhancing the detection and quantification of toxic substances within biological samples, vital for legal and medical investigations (Chernova et al., 2024).


• High-throughput microfluidic chip with silica gel-C18 channels for cyclotide separation.: Illustrates the integration of the Discovery^® C18 HPLC Column in a microfluidic setting for efficient and high-throughput separation of cyclotides, offering advancements in peptide and protein analysis (Ebrahimi et al., 2023).


• Priestia megaterium Metabolism: Isolation, Identification of Naringenin Analogues and Genes Elevated Associated with Nanoparticle Intervention.: This research utilizes the Discovery^® C18 HPLC Column for the advanced study of microbial metabolism under nanoparticle intervention, pushing the boundaries of biotechnological and pharmaceutical research (Al-Theyab et al., 2023).


• A practical strategy enabling more reliable identification of ginsenosides from Panax quinquefolius flower by dimension-enhanced liquid chromatography/mass spectrometry and quantitative structure-retention relationship-based retention behavior prediction.: Demonstrates the versatility of the Discovery^® C18 HPLC Column in complex botanical analyses, particularly in enhancing the reliability of ginsenoside identification, crucial for the development of herbal medicinal products (Sun et al., 2023).

Caratteristiche e vantaggi

• Eccellente riproducibilità
• Picchi eccezionalmente netti per analiti acidi e basici
• Separazioni LC-MS stabili e a basso spurgo
• Separazione di peptidi e piccole proteine
• L′idrofobicità inferiore rispetto a molte colonne C18 confrontabili favorisce analisi più rapide.

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Note legali

Discovery is a registered trademark of Merck KGaA, Darmstadt, Germany