Y3125

Yohimbine hydrochloride

≥98% (HPLC), powder, α2-adrenergic receptor antagonist

• Sinonimo/i: 17-Hydroxyyohimban-16-carboxylic acid methyl ester hydrochloride
• Formula empirica (notazione di Hill): C₂₁H₂₆N₂O₃ · HCl
• Numero CAS: 65-19-0
• Peso molecolare: 390.90
• Numero CE: 200-600-4
• Numero MDL: MFCD00012674
• Codice UNSPSC: 12352200
• ID PubChem: 24277814
• NACRES: NA.77

Proprietà

• Nome del prodotto: Yohimbine hydrochloride, ≥98% (HPLC), powder
• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Stato: powder
• Colore: white to off-white
• Punto di fusione: 288-290 °C (dec.) (lit.)
• Solubilità: H₂O: 10 mg/mL
• Stringa SMILE: Cl.COC(=O)[C@H]1[C@@H](O)CCC2CN3CCc4c([nH]c5ccccc45)C3CC12
• InChI: 1S/C21H26N2O3.ClH/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24;/h2-5,12,15,17-19,22,24H,6-11H2,1H3;1H/t12-,15-,17-,18-,19+;/m0./s1; PIPZGJSEDRMUAW-VJDCAHTMSA-N
• Informazioni sul gene: human ... ADRA2A(150) , ADRA2B(151) , ADRA2C(152)

Descrizione

Applicazioni

Yohimbine hydrochloride has been:

• used to study its in vitro antiviral, antibacterial and antifungal activities and cytotoxicity
• used as a tyramine receptor blocker to oppose the effects of increased tyramine in relation with flight initiation and maintenance deficits in experimental flies
• used alone and as well as with brimonidine to study the neuroprotective effect of brimonidine in the presence of glutamate-induced neurotoxicity, oxidative stress and hypoxia on in vitro cultures of purified rat retinal ganglion cells

Azioni biochim/fisiol

Yohimbine is derived from the Coryanthe yohimbe tree cortex. It is an alkaloid. Yohimbine hydrochloride is an α2-adrenergic receptor antagonist. It blocks the central α2-adrenergic receptors in the brain, thus preventing and reducing the effects of xylazine, an α2-adrenergic agonist. The sedative effects and respiratory depression that accompany xylazine administration are both antagonized and reversed by yohimbine. Yohimbine hydrochloride also produces an antidiuretic effect, and increases heart rate and blood pressure. It is useful in treating erectile dysfunction and promotes sexual functioning.

Caratteristiche e vantaggi

This compound is featured on the α2-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informazioni sulla sicurezza

• Pittogrammi: GHS06
• Avvertenze: Danger
• Indicazioni di pericolo: H300 + H330
• Consigli di prudenza: P260 - P264 - P271 - P284 - P304 + P340 + P310 - P403 + P233
• Classi di pericolo: Acute Tox. 2 Inhalation - Acute Tox. 2 Oral
• Codice della classe di stoccaggio: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges