X1875
Xanthine Oxidase from bovine milk
Grade I, ammonium sulfate suspension, ≥0.4 units/mg protein
Sinonimo/i:
XOD, Xanthine:oxygen oxidoreductase
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About This Item
Numero CAS:
Classificazione EC (Enzyme Commission):
1.17.3.2.
Numero CE:
Numero MDL:
Codice UNSPSC:
12352204
NACRES:
NA.54
Prodotti consigliati
Tipo
Grade I
Livello qualitativo
Stato
ammonium sulfate suspension
Attività specifica
≥0.4 units/mg protein
Attività estranea
uricase ≤0.5%
Condizioni di spedizione
wet ice
Temperatura di conservazione
2-8°C
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Descrizione generale
Xanthine Oxidase (XOD) is a metal flavoprotein. It has flavin adenine dinucleotide (FAD), molybdenum and iron in the ratio 2:2:8. This homodimer has a molecule weight of 290kDa. It is a member of the molybdenum-protein family. This enzyme consists of two separated substrate-binding sites.
Formerly E.C. 1.1.3.22
Applicazioni
Xanthine Oxidase from bovine milk has been used:
- in the preparation of xanthine oxidase (XO) solution for 5-(diethoxyphosphoryl)-5-methyl-1-pyrroline-N-oxide (DEPMPO)-spin trapping assay
- in in vitro XO assay for screening Vietnamese medicinal plants for XO inhibitory activity
- as a standard to determine XO activity
- as a standard to test the synergistic effect of docosahexaenoic acid (DHA)
Azioni biochim/fisiol
Hydroxylation of hypoxanthine to xanthine and xanthine to uric acid is catalyzed by xanthinebb oxidase (XO) enzyme.
Xanthine oxidase is a molybdenum-containing enzyme that is found in the cytosol, and may be strongly inhibited by flavonoids. It plays a vital role in the metabolism of some drugs, as well as purines and pyrimidines. It is also known to be a biological source of reactive oxygen species.
Xanthine oxidase was shown to be involved in the reduction of cytochrome c by the generation of superoxide anions following the oxidation of xanthine. These free radicals are responsible for reducing cytochrome c.
Definizione di unità
One unit will convert 1.0 μmole of xanthine to uric acid per min at pH 7.5 at 25 °C. Approx. 50% of the activity is obtained with hypoxanthine as substrate.
Stato fisico
Suspension in 2.3 M (NH4)2SO4 containing 1 mM sodium salicylate
Risultati analitici
Protein determined by biuret
Avvertenze
Danger
Indicazioni di pericolo
Consigli di prudenza
Classi di pericolo
Resp. Sens. 1
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, type N95 (US)
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Articoli
Instructions for working with enzymes supplied as ammonium sulfate suspensions
Protocolli
Enzymatic Assay of Superoxide Dismutase
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