W102

(R)-(+)-WIN 55,212-2 mesylate salt

≥98% (HPLC), powder, CB2 agonist

• Sinonimo/i: WIN552122
• Formula condensata: C₂₇H₂₆N₂O₃ · CH₃SO₃H
• Numero CAS: 131543-23-2
• Peso molecolare: 522.61
• Numero MDL: MFCD00153882
• Codice UNSPSC: 12352200
• ID PubChem: 24278779
• NACRES: NA.77

Proprietà

• product name: (R)-(+)-WIN 55,212-2 mesylate salt, ≥98% (HPLC)
• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Forma fisica: powder
• Controllo stupefacenti: regulated under CDSA - not available from Sigma-Aldrich Canada
• Colore: white to beige
• Solubilità: 0.1 M HCl: 0.25 mg/mL; DMSO: 12 mg/mL; 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 2.4 mg/mL; 0.1 M NaOH: insoluble; H₂O: insoluble
• Stringa SMILE: CS(O)(=O)=O.Cc1c(C(=O)c2cccc3ccccc23)c4cccc5OC[C@@H](CN6CCOCC6)n1c45
• InChI: 1S/C27H26N2O3.CH4O3S/c1-18-25(27(30)22-9-4-7-19-6-2-3-8-21(19)22)23-10-5-11-24-26(23)29(18)20(17-32-24)16-28-12-14-31-15-13-28;1-5(2,3)4/h2-11,20H,12-17H2,1H3;1H3,(H,2,3,4)/t20-;/m1./s1; FSGCSTPOPBJYSX-VEIFNGETSA-N
• Informazioni sul gene: human ... CNR1(1268) , CNR2(1269)

Descrizione

Descrizione generale

WIN 55,212-2 is a member of the aminoalkylindole class of compounds.

Applicazioni

(R)-(+)-WIN 55,212-2 mesylate salt has been used as a high affinity cannabinoid agonist for intraperitoneal injection into rats to induce behavioural sensitization. It has also been used as a synthetic cannabinoid drug and cannabinoid receptor 1 (CNR1) agonist to treat Becn2+/− mice and wild-type (WT) littermate to analyze the levels of CNR1 in the brain.

Azioni biochim/fisiol

It is known to decrease the lipopolysaccharide mediated release of tumor necrosis factor- α and interleukin-1 in mice.

Caratteristiche e vantaggi

This compound is featured on the Cannabinoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Nota sulla preparazione

The solubility of this chemical in DMF has not been determined. However, various sources state this chemical can be solubilized in about 30 mg/ml of DMF.

Note legali

Sold with the permission of Sterling-Winthrop, Inc.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)