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Key Documents

Altri documenti

UC168

Sigma-Aldrich

(±)-Bufuralol hydrochloride

Sinonimo/i:

α-[(tert-Butylamino)methyl]-7-ethyl-2-benzofuranmethanol hydrochloride

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About This Item

Formula empirica (notazione di Hill):
C16H23NO2·HCl
Numero CAS:
60398-91-6
Peso molecolare:
297.82
Numero CE:
262-216-3
Numero MDL:
MFCD00272648
Codice UNSPSC:
12161501
ID PubChem:
24724644
NACRES:
NA.77

Forma fisica

solid

Livello qualitativo

200

Colore

white to off-white

Punto di fusione

143-146 °C

Solubilità

H2O: soluble
methanol: soluble

Temperatura di conservazione

2-8°C

Stringa SMILE

Cl.CCc1cccc2cc(oc12)C(O)CNC(C)(C)C

InChI

1S/C16H23NO2.ClH/c1-5-11-7-6-8-12-9-14(19-15(11)12)13(18)10-17-16(2,3)4;/h6-9,13,17-18H,5,10H2,1-4H3;1H
KJBONRGCLLBWCJ-UHFFFAOYSA-N

Applicazioni

CYP2D6 substrate

Azioni biochim/fisiol

Bufuralol hydrochloride is known to be a non-specific β-receptor inhibitor that has an affinity for β 1 and β 2 receptors. Furthermore, studies have reported that bufuralol hydrochloride can decrease isoproterenol peripheral resistance.
β-Blocker. Varying β-adrenoceptor agonist/antagonist activity.

Caratteristiche e vantaggi

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Confezionamento

Bottomless glass bottle. Contents are inside inserted fused cone.

Nota sulla preparazione

(±)-Bufuralol hydrochloride is soluble in water and methanol.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Sigma-Aldrich

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Coumarin ≥99% (HPLC)

Sigma-Aldrich

C4261

Coumarin

Sami Haddad et al.
Journal of pharmaceutical sciences, 99(10), 4406-4426 (2010-03-24)
Drug-drug interactions (DDIs) are a great concern to the selection of new drug candidates. While in vitro screening assays for DDI are a routine procedure in preclinical research, their interpretation and relevance for the in vivo situation still represent a
Nina Nordman et al.
Journal of chromatography. A, 1218(5), 739-745 (2010-12-28)
Monolithically integrated, polymer (SU-8) microchips comprising an electrophoretic separation unit, a sheath flow interface, and an electrospray ionization (ESI) emitter were developed to improve the speed and throughput of metabolism research. Validation of the microchip method was performed using bufuralol
S S Shah et al.
Journal of veterinary pharmacology and therapeutics, 30(5), 422-428 (2007-09-07)
In this study we examined activities of cytochrome P450 (CYP)1A, 2C, 2D and 3A using hepatic microsomes from five male and five female cats. CYP1A, 2C, 2D and 3A activities were referred by ethoxyresorufin O-deethylation (EROD), tolbutamide hydroxylation (TBH), bufuralol
Evangelos P Daskalopoulos et al.
Molecular pharmacology, 82(4), 668-678 (2012-07-10)
Various hormonal and monoaminergic systems play determinant roles in the regulation of several cytochromes P450 (P450s) in the liver. Growth hormone (GH), prolactin, and insulin are involved in P450 regulation, and their release is under dopaminergic control. This study focused
Alois Bonifacio et al.
Biochemical and biophysical research communications, 343(3), 772-779 (2006-03-28)
Cytochrome P450 2D6 (CYP2D6) is one of the most important drug-metabolizing enzymes in humans. Resonance Raman data, reported for the first time for CYP2D6, show that the CYP2D6 heme is found to be in a six-coordinated low-spin state in the
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