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TRUERGD

Sigma-Aldrich

TrueGel3D RGD

Integrin Adhesion Peptide

Sinonimo/i:

3D cell culture matrix

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About This Item

Codice UNSPSC:
12352207
NACRES:
NA.71

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

Descrizione generale

RGD sequences on extracellular matrix proteins (fibronectin, vitronectin) promote cell adhesion to cellular integrin receptors. The thiol group on the N-terminus of TrueGel3D® RGD peptide acts as linker to bind RGD motif to the polymer (Dextran/PVA). The conjugated RGD motif on polymer promotes adhesion of cells with appropriate integrin receptors.
TrueGel3D® is a commercially available polymer-based diverse array of scaffolds for 3D in vitro tumor models. The RGD peptide present in these hydrogels enable cell attachment.

Applicazioni

Polymer with cell adhesion motif (RGD) employed to generate cell-adhesive hydrogel

Caratteristiche e vantaggi

Contains cell adhesion motif RGD (Acetyl-Cys-Doa*-Doa-Gly-Arg-Gly-Asp-Ser-Pro-NH2), which binds to appropriate integrin receptors on cells.

*Doa : 8-amino-3,6-dioxaoctanoic acid

Componenti

TRUERGD contains RGD degradable polymer lyophilized and water

Note legali

TRUEGEL3D is a registered trademark of Merck KGaA, Darmstadt, Germany

Codice della classe di stoccaggio

10 - Combustible liquids

Certificati d'analisi (COA)

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L P Ferreira et al.
Acta biomaterialia, 75, 11-34 (2018-05-29)
Three-dimensional multicellular tumor models are receiving an ever-growing focus as preclinical drug-screening platforms due to their potential to recapitulate major physiological features of human tumors in vitro. In line with this momentum, the technologies for assembly of 3D microtumors are

Articoli

Co-culture of Tumor and Stromal Cells in TrueGel3D™ Hydrogels

TrueGel3D™ synthetic hydrogel can be used to study co-culture of tumor and stromal cells.

Cyst Formation of MDCK Cells in TrueGel3D™ Hydrogels

TrueGel3D synthetic hydrogel can be used to study cyst formation of MDCK cells.

Utilization of TrueGel3D™ Hydrogels to Study Fibroblast Spreading

TrueGel3D™ synthetic hydrogel can be used to study fibroblast spreading.

True Gel3D™ Troubleshooting guide

TrueGel3D hydrogels kits for 3D cell culture troubleshooting guide

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Protocolli

TrueGel3D™ Fast Gelling Hydrogels Preparation Protocol

TrueGel3D™ is a chemically-defined hydrogel formed by mixing polymers with crosslinkers. This hydrogel permits the encapsulation of cells to put them in a three-dimensional environment to better mimic the native tissue environment.

TrueGel3D™ Slow Gelling Hydrogels Preparation Protocol

TrueGel3D™ is chemically defined hydrogel, enables cell growth in 3D environment and mimics native tissue environment. Slow gelation facilitates filling of microchannels or syringes. Find detail protocol of slow gelation for TrueGel3D™ kits

Contenuto correlato

Advanced Protocol: How to Customize your TrueGel3D™ Hydrogel

An advanced protocol is available for TrueGel 3D kits for 3D cell culture for peptides concentration or stiffness optimisation

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