T8931
Thyrotropic hormone from bovine pituitary
Sinonimo/i:
TSH, Thyroid stimulating hormone, Thyrotropin from bovine pituitary glands
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About This Item
Prodotti consigliati
Origine biologica
bovine pituitary glands
Livello qualitativo
Stato
powder
Confezionamento
vial of 100 μg
tecniche
cell culture | mammalian: suitable
Temperatura di conservazione
2-8°C
Informazioni sul gene
cow ... TSHB(281552)
human ... TSHR(7253)
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Descrizione generale
Thyrotropin/thyroid-stimulating hormone (TSH) belongs to the glycoprotein hormone family. This glycoprotein is produced by thyrotroph cells of the anterior pituitary gland. It circulates in free form and possess a short plasma half-life.
Applicazioni
Thyrotropic hormone from bovine pituitary has been used:
- to induce cAMP production in orbital fibroblasts.
- as a component in Dulbecco modified eagle medium (DME) H-21:F-12 media.
- for TSH stimulation test for assessing the thyroid gland function after nonthyroidal illness (NTI) induction.
- for studying the thyrotropin involvement in photoperiodic signal transduction in mice.
Azioni biochim/fisiol
Thyrotropin/thyroid-stimulating hormone (TSH) helps to regulate thyroid function. In children, TSH plays a vital role in normal cognition and neurodevelopment. Circulating TSH is capable of binding to cell surface receptors in the thyroid gland. This hormone induces thyroid to produce thyroglobulin and the thyroid hormones. TSH can also promote the uptake of iodine (131I) in individuals with thyroid cancer. It can also enhance vascular endothelial growth factor (VEGF) secretion and angiogenesis in thyroid cancer cell lines.
Two-chain glycoprotein hormone. The α-chain is not active, biological specificity attributed rather to the β-chain. Activates adenylate cyclase in the thyroid gland, stimulating iodine uptake, thyroxine synthesis and release. Goitrogenic.
Qualità
Contains phosphate buffer salts
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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Disorders of the Hypothalamic-Pituitary-Thyroid Axis
Handbook of Neuroendocrinology, 685-706 (2012)
Endocrine System
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Gen Hiyama et al.
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Lal G, et al.
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