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T5391

Sigma-Aldrich

apo-transferrina

γ-irradiated, powder, BioXtra, suitable for cell culture, ≥98%

Sinonimo/i:

Siderofilina, Transferrina umana

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About This Item

Numero CAS:
11096-37-0
Numero CE:
234-318-8
Numero MDL:
MFCD00130536
Codice UNSPSC:
12352202
NACRES:
NA.75

Livello qualitativo

200

Sterilità

γ-irradiated

Nome Commerciale

BioXtra

Saggio

≥98%

Forma fisica

powder

PM

76-81 kDa

Concentrazione

~25 mM

tecniche

cell culture | mammalian: suitable

Impurezze

HIV and HBsAg, source material tested negative
 iron, essentially free

Solubilità

H2O: 50 mg/mL

N° accesso UniProt

P02787

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

Informazioni sul gene

human ... TF(7018)

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Descrizione generale

apo-Transferrin (aTF) human can be supplemented with iron or used to bind free iron present in media. It can be used to transport iron into mammalian cells.

Applicazioni

apo-Transferrin human has been used as a supplement:
  • in Dulbecco′s modified Eagle medium/HamF12 (DMEM/F-12) to culture human adrenocortical carcinoma cells
  • in DMEM/F-12 to culture neural precursor cells from mice
  • in collecting medium NCSU23 to culture preantral follicles from porcine ovaries

Azioni biochim/fisiol

apo-Transferrin (aTF) is an endogenous iron chelator and shows protective effects in the host by scavenging free iron and preventing the formation of toxic reactive oxygen species (ROS). It shows a therapeutic effect against thalassemia. After the release of iron, receptor-bound apo-transferrin reaches the cell surface instead of being transported to lysosomes for degradation. The cell surface has a neutral pH that promotes the release of apo-transferrin from its receptor, where it can again circulate and bind additional iron to undergo further rounds of iron delivery to cells.

Altre note

Proteina di trasporto del ferro non eme.

Esclusione di responsabilità

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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In vertebrates, transferrin (Tf) safely delivers iron through circulation to cells. Tf-bound iron is incorporated through Tf receptor (TfR) 1-mediated endocytosis. TfR1 can mediate cellular uptake of both Tf and H-ferritin, an iron storage protein. New World arenaviruses, which cause
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