T4680

Terazosin hydrochloride

≥98% (TLC), powder

• Sinonimo/i: 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]piperazine hydrochloride
• Formula empirica (notazione di Hill): C₁₉H₂₅N₅O₄ · HCl
• Numero CAS: 63074-08-8
• Peso molecolare: 423.89
• Numero MDL: MFCD00467965
• Codice UNSPSC: 12352200
• ID PubChem: 24278740
• NACRES: NA.77

Proprietà

• Livello qualitativo: 200
• Saggio: ≥98% (TLC)
• Stato: powder
• Colore: white to off-white
• Solubilità: H₂O: soluble 19.60-20.40 mg/mL, clear, colorless to faintly yellow; methanol: 20 mg/mL, clear, colorless; ethanol: 4 mg/mL
• Ideatore: Abbott
• Stringa SMILE: Cl[H].COc1cc2nc(nc(N)c2cc1OC)N3CCN(CC3)C(=O)C4CCCO4
• InChI: 1S/C19H25N5O4.ClH/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;/h10-11,14H,3-9H2,1-2H3,(H2,20,21,22);1H; IWSWDOUXSCRCKW-UHFFFAOYSA-N
• Informazioni sul gene: human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146)

Descrizione

Descrizione generale

Terazosin hydrochloride is used to treat hypertension and benign prostatic hyperplasia (BPH). It is metabolised in the liver. It might be associated with dizziness, headache and asthenia. Terazosin hydrochloride is linked to acute generalized exanthematous pustulosis.

Applicazioni

Terazosin hydrochloride has been used for orthogonality and similarity analysis using reversed-phase chromatographic studies⁵. Furthermore, terazosin has also been used for the evaluation of chemometric techniques to determine orthogonality and similarity in chromatographic methods⁶.

Azioni biochim/fisiol

α₁-adrenoceptor antagonist.

Caratteristiche e vantaggi

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Nota sulla preparazione

Terazosin hydrochloride is soluble in water at 19.60 - 20.40 mg/ml and yields a clear, colorless to faint yellow solution. It is also soluble in ethanol at 4 mg/ml. Furthermore, the product is soluble in methanol at 20 mg/ml, with heat as needed, and yields a clear, colorless solution.

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H302
• Consigli di prudenza: P264 - P270 - P301 + P312 - P501
• Classi di pericolo: Acute Tox. 4 Oral
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Gloves