SRP8024
TRAIL, Soluble human
recombinant, expressed in E. coli, His tagged, >98% (SDS-PAGE)
Sinonimo/i:
Apo-2L, CD253, CD339, TRAIL
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About This Item
Codice UNSPSC:
12352200
NACRES:
NA.77
Prodotti consigliati
Origine biologica
human
Ricombinante
expressed in E. coli
Tag
His tagged
Saggio
>98% (SDS-PAGE)
Stato
liquid
PM
~26 kDa
Confezionamento
pkg of 20 μg
Concentrazione
≥0.2 mg/mL
tecniche
activity assay: suitable
cell culture | mammalian: suitable
transfection: suitable
Impurezze
<0.01 EU/μg endotoxin, tested
Colore
clear
N° accesso UniProt
Condizioni di spedizione
dry ice
Temperatura di conservazione
−70°C
Informazioni sul gene
human ... TNFSF10(8743)
Descrizione generale
TNF-related apoptosis-inducing ligand (TRAIL; Apo2L; CD253; TNFSF10) is a type II transmembrane protein of about 34kDa. Like most members of the tumor necrosis factor (TNF) superfamily of cytokines, TRAIL can be cleaved at the cell surface by metalloproteases to form a soluble molecule. The gene encoding TRAIL is localized on human chromosome 3q26.31.
Applicazioni
TRAIL, soluble human has been used in cell culture, chemical transfection and in caspase-3/7 activity assay.
Azioni biochim/fisiol
Trimerized TNF-related apoptosis-inducing ligand (TRAIL) triggers apoptosis upon ligation of cell surface TRAIL-receptor 1 (R1) and/or TRAIL-R2 by inducing the formation of the so-called multiprotein death-inducing signaling complex (DISC). Active TRAIL forms trimers and specifically binds to five distinct receptors: TRAIL-receptors 1,-2,-3,-4 {TRAIL-R1 (DR4; Apo2; CD261; TNFRSF10A), TRAIL-R2 (DR5; KILLER; TRICK2A; TRICK2B; CD262; TNFRSF10B), TRAIL-R3 (DcR1; LIT; TRID; CD263; TNFRSF10C), TRAIL-R4 (DcR2; TRUNDD; CD264; TNFRSF10D)} and osteoprotegerin (OPG; OCIF; TNFRSF11B).
Stato fisico
Solution in 20 mM HEPES, pH 7.9, 120 mM NaCl, 0.01% Tween 20, 1% sucrose, 1 mM DTT.
Altre note
The extracellular domain of human TRAIL (aa 95-281) is fused at the N-terminus to a His-tag and a linker peptide. The active multimeric conformation is stabilized by an inserted mutation allowing an additional CC-bridge.
Codice della classe di stoccaggio
12 - Non Combustible Liquids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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Intracranial AAV-sTRAIL combined with lanatoside C prolongs survival in an orthotopic xenograft mouse model of invasive glioblastoma.
Crommentuijn MH
Molecular Oncology, 10(4), 625-634 (2016)
Association between endometriosis and polymorphisms in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), TRAIL receptor and osteoprotegerin genes and their serum levels.
Kim H
Archives of Gynecology and Obstetrics, 286(1), 147-153 (2012)
Genome-Scale MicroRNA and Small Interfering RNA Screens Identify Small RNA Modulators of TRAIL-Induced Apoptosis Pathway
Dmitriy Ovcharenko
Cancer Research (2007)
Association of TRAIL and Its Receptors with Large-Artery Atherosclerotic Stroke.
Pan X
PLoS ONE, 10(9), e0136414-e0136414 (2015)
Association of Polymorphisms in TRAIL and Chronic Hepatitis B in Chinese Han Populations from Shandong Province.
Wang F
Annals of Clinical and Laboratory Science, 46(4), 374-379 (2016)
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