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Key Documents

SRP6257

Sigma-Aldrich

ADIPOQ/Adiponectin/ACRP30 human

recombinant, expressed in HEK 293 cells, ≥92% (SDS-PAGE)

Sinonimo/i:

ACDC, ACRP30, ADIPOQ, APM1, Adiponectin, GBP28

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About This Item

Codice UNSPSC:
12352202
NACRES:
NA.32

Origine biologica

human

Ricombinante

expressed in HEK 293 cells

Tag

6-His tagged (C-terminus)

Saggio

≥92% (SDS-PAGE)

Forma fisica

lyophilized powder

PM

calculated mol wt 25.4 kDa
observed mol wt 28-33 kDa (DTT-reduced. Protein migrates due to glycosylation. Glu 19 is the predicted N-terminus.)

Confezionamento

pkg of 10 μg

Impurezze

<1 EU/μg endotoxin (LAL test)

N° accesso UniProt

Q15848

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

Informazioni sul gene

human ... ADIPOQ(9370)

Descrizione generale

Adiponectin (also called Acrp30, AdipoQ) is an adipocyte specific secreted protein that circulates in the plasma. It is induced during adipocyte differentiation and its secretion is stimulated by insulin. The protein has a carboxyl-terminal globular domain and an amino-terminal collagen domain. The gene is mapped to human chromosome 3q27.

Azioni biochim/fisiol

Adiponectin (ADIPOQ) has anti-atherosclerotic and anti-inflammatory properties. ADIPOQ has a role in physiological processes such as energy homeostasis and obesity. It exhibits anti-diabetic action by interacting with adiponectin receptors, AdipoR1 and AdipoR2. Low levels of adiponectin are also linked with hypertension and dyslipidemia. Mutation in the gene encoding it is linked with risk for endometrial cancer.

Stato fisico

Lyophilized from 0.22 μm filtered solution in PBS. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.

Ricostituzione

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Effects of MCF2L2, ADIPOQ and SOX2 genetic polymorphisms on the development of nephropathy in type 1 Diabetes Mellitus.
Zhang D, et al.
BMC Medical Genetics, 11, 116-116 (2010)
Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients.
Hotta K, et al.
Arteriosclerosis, Thrombosis, and Vascular Biology, 20(6), 1595-1599 (2000)
Genetic architecture of the APM1 gene and its influence on adiponectin plasma levels and parameters of the metabolic syndrome in 1,727 healthy Caucasians.
Heid I M, et al.
Diabetes, 55(2), 375-384 (2006)
Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome.
Kadowaki T, et al.
The Journal of Clinical Investigation, 116(7), 1784-1792 (2006)
Association Between Single Nucleotide Polymorphism +276G > T (rs1501299) in ADIPOQ and Endometrial Cancer.
Bienkiewicz J, et al.
Pathology Oncology Research, 22(1), 135-138 (2016)
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