SRP6057

Activin A from mouse

recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)

• Sinonimo/i: FRP, FSH-releasing protein, Inhibin beta-1
• Codice UNSPSC: 12352202
• NACRES: NA.32

Proprietà

• Origine biologica: mouse
• Ricombinante: expressed in E. coli
• Saggio: ≥95% (HPLC); ≥95% (SDS-PAGE)
• Forma fisica: lyophilized
• PM: 26.2 kDa
• Confezionamento: pkg of 10 μg
• tecniche: cell culture | embryo: suitable
• N° accesso NCBI: P08476
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: −20°C
• Informazioni sul gene: mouse ... INHBA(3624)

Descrizione

Descrizione generale

Activin A is a member of the TGF (transforming growth factor)-β family of proteins produced by many cell types throughout development. Mouse Activin A has 100% amino acid sequence identity to human, rat, porcine, bovine and feline proteins. Recombinant mouse Activin A is a nonglycosylated homodimer, containing two 117 amino acid chains, with a total molecular weight of 26.2 kDa.

Applicazioni

Activin A has been used:

• to induce differentiation of embryonic stem cells to pancreatic β cells
• in the induction of bone marrow-derived mesenchymal stem cells to insulin-producing cells
• to induce endoderm differentiation from human embryonic stem cells
• as a component of β cell induction medium.

Azioni biochim/fisiol

Activins interact with Type I and Type II serine/threonine kinases to signal to SMAD proteins to regulate a variety of functions, including cell proliferation, differentiation, wound healing, apoptosis, metabolism, etc. Activin A is a homodimer of two β A chains and is not biologically active until the N terminal propeptide is cleaved from each chain. Activin A is involved in mesoderm formation and hematopoietic development.

Stato fisico

Recombinant mouse Activin A is lyophilized with 0.02% TFA.

Nota sulla preparazione

Centrifuge the vial prior to opening.

Ricostituzione

Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile water, which can then be further diluted to other aqueous solutions.

Altre note

MGLECDGKVN ICCKKQFFVS FKDIGWNDWI IAPSGYHANY CEGECPSHIA GTSGSSLSFH STVINHYRMR GHSPFANLKS CCVPTKLRPM SMLYYDDGQN IIKKDIQNMI VEECGCS

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H315,H319
• Consigli di prudenza: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• Classi di pericolo: Eye Irrit. 2 - Skin Irrit. 2
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable