SRP3263
G-CSF human
Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)
Sinonimo/i:
CSF-3, GM-CSF?, MGI-1G, pluripoietin
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About This Item
Codice UNSPSC:
12352202
NACRES:
NA.32
Prodotti consigliati
Origine biologica
human
Ricombinante
expressed in E. coli
Saggio
≥98% (HPLC)
≥98% (SDS-PAGE)
Stato
lyophilized
Potenza
10.0-25.0 ng/mL
PM
18.7 kDa
Confezionamento
pkg of 10 μg
Impurezze
<0.1 EU/μg endotoxin, tested
Colore
white to off-white
N° accesso UniProt
Condizioni di spedizione
wet ice
Temperatura di conservazione
−20°C
Informazioni sul gene
human ... CSF3(1440)
Descrizione generale
Granulocyte colony stimulating factor (G-CSF) or colony stimulating factor 3 (CSF-3) is produced in response to specific stimulation by a variety of cells including macrophages, fibroblasts, endothelial cells and bone marrow stroma. Human and murine G-CSF are cross-species reactive. The gene encoding G-CSF is localized on human chromosome 17. Recombinant human G-CSF is an 18.7kDa protein consisting of 174 amino acid residues.
Azioni biochim/fisiol
Granulocyte colony stimulating factor (G-CSF) or colony stimulating factor 3 (CSF-3) is a hematopoietic growth factor that stimulates the development of committed progenitor cells to neutrophils and enhances the functional activities of the mature end-cell. It controls the production, differentiation and function of granulocytes. G-CSF is being used clinically to facilitate hematopoietic recovery after bone marrow transplantation. The protein has been shown to have a role in bone repair in animal models and clinically approved for neutropenia treatment.
Stato fisico
Lyophilized from 5 mM Sodium Citrate, pH 4.0.
Ricostituzione
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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I clienti hanno visto anche
Frequent loss of heterozygosity on chromosome 17 at 17q11.2-q12 in Barrett's adenocarcinoma.
Swift A
British Journal of Cancer, 71(5), 995-998 (1995)
Effect of Granulocyte-Colony Stimulating Factor on Endothelial Cells and Osteoblasts.
Liu XL
BioMed Research International, 8485721-8485721 (2016)
Administration of granulocyte colony-stimulating factor with radiotherapy promotes tumor growth by stimulating vascularization in tumor-bearing mice.
Kim JS
Oncology Reports, 34(1), 147-154 (2015)
H S Lu et al.
Archives of biochemistry and biophysics, 268(1), 81-92 (1989-01-01)
Molecular characteristics and secondary structures of recombinant methionyl human granulocyte colony stimulating factor produced by genetically engineered Escherichia coli are described. Limited radiolabeling of the protein with tritiated iodoacetate and determination of the labeled residue revealed that this recombinant protein
Protective role of G-CSF in dextran sulfate sodium-induced acute colitis through generating gut-homing macrophages.
Meshkibaf S
Cytokine, 78, 69-78 (2016)
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