SML3780

Nintedanib ethanesulphonate

≥98% (HPLC)

• Sinonimo/i: (3Z)-2,3-Dihydro-3-[[[4-[methyl[2-(4-methyl-1-piperazinyl)acetyl]amino]phenyl]amino]phenylmethylene]-2-oxo-1H-indole-6-carboxylic acid methyl ester, monoethanesulphonate salt, (Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino}phenylamino)methylene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester, monoethanesulphonate salt, BIBF 1120 esylat, BIBF-1120 esylate, BIBF1120 esylate, Methyl (Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate, monoethanesulphonate salt, Nintedanib monoethanesulphonate salt
• Formula empirica (notazione di Hill): C₃₁H₃₃N₅O₄·C₂H₆O₃S
• Numero CAS: 656247-18-6
• Peso molecolare: 649.76
• Numero MDL: MFCD26142360
• Codice UNSPSC: 12352200
• NACRES: NA.21

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Forma fisica: powder
• Condizioni di stoccaggio: desiccated
• Colore: white to beige
• Solubilità: DMSO: 2 mg/mL, clear (Warmed)
• Temperatura di conservazione: -10 to -25°C

Descrizione

Azioni biochim/fisiol

Nintedanib (BIBF1120) is an orally active, potent ATP-competitive inhibitor against angiokinases VEGFR-1/2/3 (IC50 = 34/21/13 nM), FGFR-1/2/3/4 (IC50 = 69/37/108/610 nM), PDGFRα/β (IC50 = 59/65 nM), as well as Flt-3, Lck, Lyn, and Src (IC50 = 26, 16, 195, 156 nM, repectively), but not 33 other kinases. Nintedanib exhibits antiangiogenic and antifibrotic efficacy in cultures and in animal models of cancers and pulmonary fibrosis in vivo.

Avvertenza

Hygroscopic

Informazioni sulla sicurezza

• Pittogrammi: GHS08,GHS09
• Avvertenze: Danger
• Indicazioni di pericolo: H360D,H372,H411
• Consigli di prudenza: P202 - P260 - P264 - P273 - P280 - P308 + P313
• Classi di pericolo: Aquatic Chronic 2 - Repr. 1B - STOT RE 1
• Organi bersaglio: Liver,Gastro-intestinal system
• Codice della classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable