SML3005

NMDAR/TRPM4 interface inhibitor C19 dihydrochloride

≥98% (HPLC)

• Sinonimo/i: 2-(3-(Aminomethyl)pyrrolidin-1-yl)-N-(2,4,5-trichlorophenyl)acetamide dihydrochloride, C19 dihydrochloride, Compound 19 dihydrochloride, N-(2,4,5-Trichlorophenyl)-3-aminomethyl-1-pyrrolidineacetamide dihydrochloride
• Formula empirica (notazione di Hill): C₁₃H₁₆Cl₃N₃O·2HCl
• Numero CAS: 2241128-93-6
• Peso molecolare: 409.57
• Numero MDL: MFCD31666003
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Stato: powder
• Colore: white to beige
• Solubilità: H₂O: 2 mg/mL, clear
• Temperatura di conservazione: −20°C
• Stringa SMILE: O=C(CN1CC(CC1)CN)NC2=CC(Cl)=C(C=C2Cl)Cl.Cl.Cl
• InChI: 1S/C13H16Cl3N3O.2ClH/c14-9-3-11(16)12(4-10(9)15)18-13(20)7-19-2-1-8(5-17)6-19;;/h3-4,8H,1-2,5-7,17H2,(H,18,20);2*1H; KKZAEWKBOQYGHO-UHFFFAOYSA-N

Descrizione

Azioni biochim/fisiol

Compound 19 (C19) is a small molecule that directly targets TRPM4 TwinF domain and blocks its interaction with GluN2A/GluN2B (NR2A/NR2B) I4 domain. C19 prevents NMDAR/TRPM4 interaction-dependent excitotoxicity (death protection EC50 = 1.1 μM 24 h post 10-min exposure of primary murine hippocampal neurons to 20 μM NMDA) without affecting, and even enhancing, NMDAR-mediated essential functions.

TRPM4 TwinF domain-targeting NMDAR/TRPM4 interaction blocker that protects against TRPM4-mediated excitotoxicity.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable