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SML2486

Sigma-Aldrich

Peramivir trihydrate

≥98% (HPLC)

Sinonimo/i:

(1S,2S,3R,4R)-3-[(1S)-1-(Acetylamino)-2-ethylbutyl]-4-[(aminoiminomethyl)amino]-2-hydroxycyclopentanecarboxylic acid trihydrate

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About This Item

Formula empirica (notazione di Hill):
C15H28N4O4 · 3H2O
Numero CAS:
1041434-82-5
Peso molecolare:
382.45
Codice UNSPSC:
51111800
NACRES:
NA.77

Saggio

≥98% (HPLC)

Stato

powder

Attività ottica

[α]/D -125 to -145°, c = 0.1 in H2O

Colore

white to beige

Solubilità

DMSO: 2 mg/mL, clear

Temperatura di conservazione

2-8°C

Stringa SMILE

N([C@H]1[C@@H]([C@@H]([C@H](C1)C(=O)O)O)[C@@H](NC(=O)C)C(CC)CC)C(=N)N.O.O.O

InChI

1S/C15H28N4O4.3H2O/c1-4-8(5-2)12(18-7(3)20)11-10(19-15(16)17)6-9(13(11)21)14(22)23;;;/h8-13,21H,4-6H2,1-3H3,(H,18,20)(H,22,23)(H4,16,17,19);3*1H2/t9-,10+,11+,12-,13+;;;/m0.../s1
RFUCJKFZFXNIGB-ZBBHRWOZSA-N

Azioni biochim/fisiol

Influenza viral neuraminidase inhibitor
Peramivir exhibits antiviral activity against type A and B influenza virus including pandemic influenza A/H1N1 virus. It also exhibits its antiviral effects on avian influenza viruses like H5N1 and H9N2 strains.
Peramivir is an Influenza viral neuraminidase inhibitor.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number

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Jung-Wan Yoo et al.
Journal of medical virology, 87(10), 1649-1655 (2015-05-07)
The clinical efficacy of peramivir in the treatment of severe seasonal influenza in critically ill patients admitted to an intensive care unit (ICU) is not well established. The aim of this study was to compare the clinical efficacy of peramivir
Masanori Kobayashi et al.
Antiviral research, 139, 41-48 (2016-12-26)
High morbidity and mortality associated with human cases of highly pathogenic avian influenza (HPAI) viruses, including H5N1 influenza virus, have been reported. The purpose of the present study was to evaluate the antiviral effects of peramivir against HPAI viruses. In
Zhengtu Li et al.
BMC infectious diseases, 16, 325-325 (2016-07-10)
China-made Peramivir, an anti-influenza neuraminidase inhibitor drug, is manufactured and widely used in China. Although effective if initiated within 48 h of the onset of symptoms, yet we observed that this drug shows an inconclusive efficacy if treatment is delayed in

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