SML2198

sAJM589

≥98% (HPLC)

• Sinonimo/i: 5-Hydroxybenzo[a]phenazine, Benzo[a]phenazin-5-ol
• Formula empirica (notazione di Hill): C₁₆H₁₀N₂O
• Numero CAS: 2089-82-9
• Peso molecolare: 246.26
• Numero MDL: MFCD00437759
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• Saggio: ≥98% (HPLC)
• Stato: powder
• Colore: yellow to orange
• Solubilità: DMSO: 2 mg/mL, clear (warmed)
• Temperatura di conservazione: −20°C
• Stringa SMILE: OC1=C2C(C=CC=C2)=C3C(N=C(C=CC=C4)C4=N3)=C1
• InChI: WZBDRAAGHRCRKM-UHFFFAOYSA-N

Descrizione

Azioni biochim/fisiol

Myc inhibitor that disrupts the Myc-Max heterodimer

sAJM589 is a Myc inhibitor that disrupts the Myc-Max heterodimer with an IC50 value of 1.8 μM. sAJM589 was shown to suppress cellular proliferation in a variety of MYC-dependent cancer cell line including strong inhibition of Burkitt lymphoma Raji cell line growth. The mechanism of action of sAJM589 is thought to involve increased ubiquitination of Myc by inhibition of Max binding to Myc, leading to proteasome-mediated degradation.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable