Passa al contenuto
Merck
Tutte le immagini(1)

Documenti fondamentali

Visualizza tutta la documentazione

SML1766

Sigma-Aldrich

Diphyllin

≥98% (HPLC)

Sinonimo/i:

9-(1,3-Benzodioxol-5-yl)-4-hydroxy-6,7-dimethoxy-naphtho[2,3-c]furan-1(3H)-one, NSC 309691

Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali
Tutte le immagini(1)

About This Item

Formula empirica (notazione di Hill):
C21H16O7
Numero CAS:
22055-22-7
Peso molecolare:
380.35
Numero MDL:
MFCD00808222
Codice UNSPSC:
12352200
ID PubChem:
329826058
NACRES:
NA.77

Livello qualitativo

100

Saggio

≥98% (HPLC)

Stato

powder

Colore

white to light brown

Solubilità

DMSO: 5 mg/mL, clear (warmed)

Temperatura di conservazione

2-8°C

Stringa SMILE

OC1=C2C(C(OC2)=O)=C(C3=CC=C(OCO4)C4=C3)C5=CC(OC)=C(OC)C=C51

InChI

1S/C21H16O7/c1-24-15-6-11-12(7-16(15)25-2)20(22)13-8-26-21(23)19(13)18(11)10-3-4-14-17(5-10)28-9-27-14/h3-7,22H,8-9H2,1-2H3
VMEJANRODATDOF-UHFFFAOYSA-N

Descrizione generale

Diphyllin, a major glycoside compound, is a plant-derived lignan. It is present in Cleistanthus collinus.

Applicazioni

Diphyllin has been used to study its antibacterial and antibiofilm activities against fish pathogens.

Azioni biochim/fisiol

Diphyllin has shown potential to be used in a novel treatment for bone problems characterized by excessive resorption.
Diphyllin is a natural arylnaphthalene that exhibits potent anticancer and antiviral activities.
Diphyllin is a natural arylnaphthalene that exhibits potent anticancer and antiviral activities. It is a potent inhibitor of vacuolar H(+)-ATPase (V-ATPase) that inhibits lysosomal acidification in osteoclasts.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Scegli una delle versioni più recenti:

Certificati d'analisi (COA)

Lot/Batch Number
116M4723V

Non trovi la versione di tuo interesse?

Se hai bisogno di una versione specifica, puoi cercare il certificato tramite il numero di lotto.

Cerca un COA

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

Mette G Sørensen et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 22(10), 1640-1648 (2007-06-20)
Dissolution of the inorganic phase of bone by the osteoclasts mediated by V-ATPase and ClC-7 is a prerequisite for bone resorption. Inhibitors of osteoclastic V-ATPase or ClC-7 are novel approaches for inhibition of osteoclastic bone resorption. By testing natural compounds
Zhitao Zhang et al.
European journal of medicinal chemistry, 82, 466-471 (2014-06-16)
The concise syntheses of two natural diphyllin glycosides Cleistanthin-A (CA), Cleistanthoside-A (CleA) and its derivative, Cleistanthoside-A tetraacetate (CleT), have been achieved. They were evaluated for their in vitro anti-proliferative activities against MCF-7, HeLa, HepG2, HCT-116, U251 cancer cell lines by
Yapeng Lu et al.
European journal of pharmacology, 771, 130-138 (2015-12-23)
The vacuolar H(+)-ATPase (V-ATPase) has recently been proposed as a key target for new strategies in cancer treatment. Our previous work has proved that diphyllin glycoside is a novel inhibitor of V-ATPase. Here the cytotoxic effects of ZT-25, the most

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica.